Gynecology Book


Fourth Generation Progestin

Aka: Fourth Generation Progestin, Desogestrel, Gestodene, Norgestimate
  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Class
    1. 19 Nor-TestosteroneProgestin: Gonane
  3. Preparations: Desogestrel
    1. Relative Progestational Activity: 9.0
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 3.4
      3. Endometrial Activity: 8.7
    2. Preparations
      1. Desogen (0.15/30)
      2. Ortho-Cept (0.15/30)
      3. Mircette (0.15/20)
      4. Cyclessa (triphasic: 0.100 - 0.125 - 0.150 / 25)
  4. Preparations: Gestodene
    1. Relative Progestational Activity: 12.6
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 8.6
      3. Endometrial Activity: 12.6
    2. Preparations
      1. Melodene (Spain) or Minesse (Israel) (0.060/15)
      2. Femodette (UK, 0.075/20)
      3. Femodene or Minulet (UK, 0.075/30)
      4. Triadene or Tri-Minulet (UK, 0.050/30 - 0.070/40 - 0.1/30)
  5. Preparations: Norgestimate
    1. Relative Progestational Activity: 1.3
      1. Estrogenic Activity: 0
      2. Androgenic Activity: 1.9
      3. Endometrial Activity: 1.2
    2. Preparations
      1. Ortho-Cyclen (0.15/30)
      2. Ortho Tri-Cyclen (0.18/35 - 0.25/35)
  6. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
    2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
    3. Dickey (1998) Managing Contraceptive Pill Patients

Desogestrel (C0057558)

Definition (NCI) A synthetic progestogen structurally related to levonorgestrel, with progesterone hormone receptor agonistic activity, used as a contraceptive and hormone replacement agent. Upon administration, desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA causing either gene transcription or gene repression. This eventually leads to an inhibition of gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and a subsequent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This prevents ovulation and alters the cervical mucus.
Definition (MSH) A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D017135
SnomedCT 116074007, 326306004, 126108008
English 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol, Desogestrel, 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol, 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17alpha)-, 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol, desogestrel, DESOGESTREL, Desogestrel [Chemical/Ingredient], alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17, Desogestrel (substance), Desogestrel preparation (product), Desogestrel preparation, Desogestrel product, Desogestrel [dup] (substance), Desogestrel preparation (substance)
Swedish Desogestrel
Czech desogestrel
Finnish Desogestreeli
Japanese デソゲストレル
Spanish desogestrel (producto), preparado con desogestrel (producto), preparado con desogestrel, desogestrel (sustancia), desogestrel, preparado de desogestrel (sustancia), Desogestrel
Italian 13-Etil-11-metilene-18,19-dinor-17 alfa-pregn-4-en-20-yn-17-ol, Desogestrel
Polish Dezogestrel
French Désogestrel
German Desogestrel
Portuguese Desogestrel
Derived from the NIH UMLS (Unified Medical Language System)

Gestodene (C0061246)

Concepts Pharmacologic Substance (T121) , Steroid (T110)
MSH C033273
SnomedCT 437760006, 326352006, 395945000
English 13-ethyl-17-hydroxy-18,19-dinor-17 alpha-pregna-4,15-dien-20-yn-3-one, 17-alpha-ethinyl-13-ethyl-17 beta-hydroxy-4,15-gonadien-3-one, Gestoden, Gestodene, Gestodene [combined oc], Gestodene [combined oral contraceptive], Gestodene (product), gestoden, gestodene, Gestodene [combined oral contraceptive] (product), Pregna-4,15-Dien-20-Yn-3-One, 13-Ethyl-17-Hydroxy-18,19-Dinor-, (17Alpha)-, 13-Ethyl-17-Hydroxy-18,19-Dinor-17Alpha-Pregna-4,15-Dien-20-Yn-3-One, GESTODENE, 18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)-, Gestodene (substance), Gestodene [combined oral contraceptive] (substance)
Spanish gestodeno (producto), gestodeno (anticonceptivo oral combinado), gestodeno (anticonceptivo oral combinado) (producto), gestodeno (sustancia), gestodeno
Derived from the NIH UMLS (Unified Medical Language System)

norgestimate (C0068992)

Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH C017576
SnomedCT 326362004, 126115000, 116073001
English norgestimate, Norgestimate [combined oc], NORGESTIMATE, norgestimate [Chemical/Ingredient], Norgestimate [combined oc] (product), Norgestimate (substance), Norgestimate preparation (product), Norgestimate preparation, Norgestimate, Norgestimate [combined oc] (substance), Norgestimate preparation (substance)
Spanish preparado con norgestimato (producto), norgestimato (producto), preparado con norgestimato, norgestimato (anticonceptivo oral combinado), norgestimato (anticonceptivo oral combinado) (producto), norgestimato (sustancia), norgestimato, preparado de norgestimato (sustancia)
Derived from the NIH UMLS (Unified Medical Language System)

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