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Addyi
Aka: Addyi, Flibanserin
- See Also
- Female Sexual Dysfunction
- Indications
- Hypoactive sexual drive in women (libido)
- Mechanism
- Serotonin Agonist-antagonist
- Does not increase sexual organ blood flow (unlike Phosphodiesterase Inhibitors such as Viagra)
- Dosing
- One tablet daily at bedtime
- Efficacy
- Premenopausal women may experience 1 more satisfying sexual encounter in 1-2 months (NNT 11)
- Only effective if consistently taken daily (and may take 8 weeks of continuous use for full effect)
- Adverse Effects
- Hypotension (especially in liver disease, when taken with Alcohol or when taken with CYP3A4 Inhibitor)
- Systolic Blood Pressure dropped >50 mmHg in some cases when combined with Alcohol (NNH 6)
- Disadvantages
- Marginal efficacy in premenopausal women (and less effective in postmenopausal women)
- Expensive ($350/month)
- Severe Hypotension may occur (esp. with Alcohol, CYP3A4 inhibitors)
- Prescribers must undergo REMS training before prescribing
- http://www.accessdata.fda.gov/scripts/cder/rems/index.cfm?event=IndvRemsDetails.page&REMS=350
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Drug Interactions
- CYP3A4 inhibitors (e.g. Fluconazole, Grapefruit)
- Avoid CYP3A4 inhibitors for 2 weeks before starting Addyi and for 2 days after stopping
- Single dose of a strong CYP3A4 inhibitor could significantly raise Addyi doses with Hypotension risk
- References
- (2015) Presc Lett 22(10):60