Gynecology Book

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Serum Estradiol

Aka: Serum Estradiol, Estradiol
  1. See Also
    1. Estrogen
  2. Definitions
    1. Estrogens
      1. Estrogens are synthesized in vivo and maintain female sex characteristics
      2. Estrogens target receptors in gynecologic organs, as well as male Ledigs Cells and Prostate Glands, and heart, skin, Kidney, liver, brain
    2. Estradiol
      1. Most potent, natural form of Estrogens in humans
  3. Physiology
    1. Images
      1. menstrualCycle.png
    2. Estrogen effects
      1. Breast development (ducts, fat)
      2. Female genitalia
      3. Secondary sex characteristics
      4. Uterine endometrial lining proliferation in the Proliferative Phase of menstual cycyle
    3. Symptoms associated with physiologic increased Estrogen levels (e.g. Premenstrual Syndrome)
      1. Swollen or engorged Breast tenderness
      2. Water retention
      3. Irritability (decreased Serotonin)
      4. Headaches
      5. Visual disturbance
      6. Memory difficulty
      7. Sweet craving
    4. Excess Estrogen effects (e.g. Oral Contraceptives)
      1. Contraception
        1. Limits FSH and LH rise, preventing Ovulation
        2. Cervical Mucus thickening (more hostile to sperm)
        3. Inhibit ovum implantation in Uterus
      2. Adverse effects
        1. See Oral Contraceptives for adverse effects
        2. Venous Thromboembolism Risk
        3. Endometrial Hyperplasia or Endometrial Cancer (Unopposed Estrogen, without Progesterone)
        4. Hypertension
    5. Estrogen Deficiency
      1. See Menopause
      2. See Premature Ovarian Failure
      3. Hot Flushes
      4. Vaginal Atrophy
      5. Osteoporosis
  4. Labs: Normal Levels
    1. Male: 6 to 46 pg/ml
    2. Female
      1. Follicular Phase: 30 to 90 pg/ml
      2. Luteal Phase: 70 to 300 pg/ml

Estradiol (C0014912)

Definition (CHV) a steroid sex hormone
Definition (CHV) a steroid sex hormone
Definition (CHV) a steroid sex hormone
Definition (CHV) a steroid sex hormone
Definition (CHV) a steroid sex hormone
Definition (CHV) a steroid sex hormone
Definition (CHV) a steroid sex hormone
Definition (NCI_NCI-GLOSS) A form of the hormone estrogen.
Definition (NCI) A steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Typically esterified, estradiol derivatives are formulated for oral or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability.
Definition (NCI) The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.
Definition (MSH) The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Definition (CSP) generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position; estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Definition (PDQ) A steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Typically esterified, estradiol derivatives are formulated for oral or parenteral administration. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39236&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39236&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C478" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D004958
SnomedCT 12839006, 126172005, 76780005, 126177004, 326188008, 116114000
LNC LP69846-1, LP14497-9, MTHU003161
English 17 beta Estradiol, 17 beta Oestradiol, 17 beta-Estradiol, 17 beta-Oestradiol, Estradiol, Estradiol 17 beta, Estradiol-17 beta, Estra-1,3,5(10)-triene-3,17-diol (17beta)-, Estradiol [gynae], Oestradiol [gynae], Oestradiol, (17beta)-Estra-1,3,5(10)-triene-3,17-diol, 17-beta-Estradiol, estradiol, Therapeutic Estradiol, 17 Beta-Estradiol, BETA ESTRADIOL 17, ESTRADIOL A 017 BETA, ESTRADIOL, 17 beta-estradiol preparation, 17 beta-oestradiol preparation, Oestradiol preparation, estradiol (medication), Oestradiol -RETIRED-, Estradiol [Chemical/Ingredient], oestradiol, 17 beta estradiol, 17beta estradiol, 17-beta oestradiol, estradiols, 17 beta-estradiol, 17 beta-estradiol (substance), Estradiol [gynae] (product), 17 beta-oestradiol, 17 beta-estradiol preparation (product), Estradiol [gyne], Estradiol Anhydrous, Estradiol 17beta, Estradiol-17beta, Estradiol preparation, Estradiol product, Oestradiol product, 17-Beta estradiol, 17-Beta oestradiol, E2 - Estradiol, E2 - Oestradiol, Estradiol (substance), Estradiol preparation (product), Estraldine, ESDL, Estradiol -RETIRED-, Estradiol [gynae] (substance), Estradiol preparation (substance), 17 beta-estradiol preparation (substance), ESTRADIOL 17-BETA
Swedish Östradiol
Czech estradiol
Spanish preparado de 17 beta estradiol, estradiol (producto), preparado de estradiol (producto), preparado de estradiol, 17 beta - estradiol, estradiol - RETIRADO - (concepto no activo), 17 beta-estradiol (sustancia), estradiol [uso ginecológico], estradiol - RETIRADO -, preparado de 17 beta-estradiol (producto), 17 beta-estradiol, preparado de 17 beta-estradiol, estradiol [uso ginecológico] (producto), estradiol (sustancia), estradiol, preparado de 17 beta-estradiol (sustancia), preparado de estradiol (sustancia), Estradiol, 17 beta-Estradiol, Estradiol-17 beta, Oestradiol
Finnish Estradioli
French Oestradiol-17beta, 17bêta Oestradiol, Oestradiol 17beta, 17beta Oestradiol, 17bêta-Oestradiol, Estradiol, Oestradiol-17bêta, 17beta-Oestradiol, Oestradiol 17bêta, Oestradiol
Italian 17-beta oestradiolo, 17-beta estradiolo, Estradiolo
Russian 17-BETA-ESTRADIOL, ESTRADIOL, ESTRADIOL-17-BETA, ESTRADIOLA BENZOAT, 17-БЕТА-ЭСТРАДИОЛ, ЭСТРАДИОЛ-17-БЕТА, ЭСТРАДИОЛ, ЭСТРАДИОЛА БЕНЗОАТ
Japanese 17β-エストラジオール, エストラジオール, エストラジオール-17ベータ, エストラジオール-17β, 17ベータ-エストラジオール
German BETA ESTRADIOL 17, ESTRADIOL A 017 BETA, 17-Beta-Estradiol, Estradiol, 17-Beta-, Estradiol, Östradiol
Croatian ESTRADIOL
Polish Estradiol
Norwegian 17 beta-østradiol, Oestradiol, Østradiol, Østradiol-17beta
Portuguese 17 beta-Estradiol, Estradiol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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