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Markers of Ovarian Reserve
Aka: Markers of Ovarian Reserve, Ovarian Reserve Assessment
- See Also
- Secondary Amenorrhea
- Menopause
- Premature Ovarian Failure
- Physiology
- Ovarian follicles decrease with aging to Perimenopause (thousands of follicles) to Menopause (<1000 follicles)
- Labs
- Anti-Mullerian Hormone (AMH)
- Stable marker of ovarian reserve (gradually declines from age 25 to Menopause)
- AMH <1.0 suggests decreased ovarian reserve
- Follicle Stimulating Hormone (FSH)
- Obtain on day 3 of cycle
- FSH >10 IU/L suggest decreased ovarian reserve (but poor reliability due to variable levels)
- Estradiol (E2)
- Obtain on day 3 of cycle
- Estradiol decreased in decreased ovarian reserve
- Imaging
- Pelvic Ultrasound
- Ovarian Volume
- Antral follicle count
- Count follicles 2-10 mm in diameter during early Follicular Phase
- References
- kruszynska (2017) Prz Menopauzalny 16(2): 47-50 +PMID:28721129 [PubMed]
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509971/