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BRCA1
Aka: BRCA1- Location
- Chromosome 17
- Epidemiology
- More common in Ashkenazi Jewish women
- Does not affect males (unlike BRCA2)
- Responsible for a third of hereditary Breast Cancer
- Defective gene connotes:
- Ovarian Cancer risk: 40-60%
- Breast Cancer risk: 90%
- Age 20-29: Relative Risk Breast Cancer 106
- Age 30-39 Relative Risk Breast Cancer 44
- Age 40-49: Relative Risk Breast Cancer 15
- Age 50-59: Relative Risk Breast Cancer 8.2
- Age 60-69: Relative Risk Breast Cancer 2.8
- Chen (2006) j clin oncol 24(6): 863-71 [PubMed]
- Metcalfe (2018) Clin Genet 93(5): 1063-8 [PubMed]
- References