Gastroenterology Book


Prevention of Liver Disease Progression

Aka: Prevention of Liver Disease Progression, Chronic Liver Disease
  1. Causes
    1. Alcoholic Cirrhosis and other toxin induced causes
    2. Infectious Hepatitis
      1. Hepatitis B
      2. Hepatitis C
    3. Autoimmune Conditions
      1. Primary Sclerosing Cholangitis
      2. Primary biliary Cirrhosis
      3. Autoimmune Hepatitis
    4. Hereditary causes
      1. Hemochromatosis
      2. Alpha-1-Antitrypsin Deficiency
      3. Wilson's Disease
      4. Non-Alcoholic Steatohepatitis
  2. Prevention of Liver Disease Progression
    1. Abstain completely from Alcohol
    2. Vaccination
      1. Hepatitis A Vaccine
      2. Hepatitis B Vaccine
    3. Avoid Hepatotoxic Medications
      1. Acetaminophen <2 grams/day appears to be safe
      2. Statins appear to be safe
      3. Avoid frequent NSAIDs or Aspirin (bleeding risk)
      4. Antibiotics
        1. Avoid Augmentin
        2. Fluoroquinolone and Cephalosporins are safe
    4. Avoid iron Supplements except in Iron Deficiency Anemia
      1. Reduces risk of Secondary Hemochromatosis
    5. Low Fat Diet
      1. Reduces risk of Fatty Liver
  3. References
    1. Riley (2001) Am Fam Physician 64(9):1555-60 [PubMed]

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