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Promethazine
Aka: Promethazine, Phenergan- Indications
- Nausea or Vomiting
- Motion Sickness or Vertigo
- Other agents are preferred (e.g. Dimenhydrinate)
- Mechanism
- Contraindications
- Do not use under age 2 years
- Adverse Effects
- Excessive sedation
- Respiratory Depression
- Apnea and death have occurred in children
- Precautions
- Long plasma half-life (observe prior to discharge)
- Lowers Seizure threshold
- Avoid use in children (absolutely contraindicated <2yo)
- Dosing
- Precautions: IV dosing used but not FDA labeled
- Adults: 12.5 to 25 mg PO/IM/PR q4-6 hours
- Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours
- Maximum: 25 mg per dose
- Efficacy
- Less effective Antiemetic than Prochlorperazine (Compazine) in ER patients
- Sedation may delay Emergency Department discharge
- References
- Johnson (1993) Harriet Lane, Mosby, p. 521
- (2002) Tarascon Pocket Pharmacopoeia, p. 67
Medication Costs | ||
---|---|---|
Promethazine DM syrup (on 6/18/2017 at Walmart.com) | ||
Promethazine DM syrup | #120 ml for $4.00 | $0.03 each |
Promethazine DM syrup | #360 ml for $10.00 | $0.03 each |
Promethazine (on 6/18/2017 at Walmart.com) | ||
Promethazine 25mg | #12 tablets for $4.00 | $0.33 each |
Promethazine 25mg | #36 tablets for $10.00 | $0.28 each |
Promethazine plain syrup (on 6/18/2017 at Walmart.com) | ||
Promethazine plain syrup | #180 ml for $4.00 | $0.02 each |
Promethazine plain syrup | #540 ml for $10.00 | $0.02 each |
promethazine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
PROMETHAZINE 12.5 MG SUPPOS | Generic | $7.67 each |
PROMETHAZINE 12.5 MG TABLET | Generic | $0.09 each |
PROMETHAZINE 25 MG SUPPOSITORY | Generic | $7.23 each |
PROMETHAZINE 25 MG TABLET | Generic | $0.06 each |
PROMETHAZINE 25 MG/ML AMPUL | Generic | $1.31 per ml |
PROMETHAZINE 25 MG/ML VIAL | Generic | $1.21 per ml |
PROMETHAZINE 50 MG SUPPOSITORY | Generic | $31.00 each |
PROMETHAZINE 50 MG TABLET | Generic | $0.18 each |
PROMETHAZINE 6.25 MG/5 ML SYRP | Generic | $0.02 per ml |
PROMETHAZINE VC SYRUP | Generic | $0.21 per ml |
PROMETHAZINE VC-CODEINE SYRUP | Generic | $0.39 per ml |
PROMETHAZINE-CODEINE SYRUP | Generic | $0.03 per ml |
PROMETHAZINE-DM SOLUTION | Generic | $0.01 per ml |
PROMETHAZINE-DM SYRUP | Generic | $0.02 per ml |
PROMETHAZINE-PE-CODEINE SYRUP | Generic | $0.39 per ml |
PROMETHAZINE-PHENYLEPHRINE SYR | Generic | $0.21 per ml |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Promethazine (C0033405) |
|
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Definition (CHV) | a drug used to treat allergy symptoms |
Definition (CHV) | a drug used to treat allergy symptoms |
Definition (NCI) | A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities. |
Definition (MSH) | A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D011398 |
SnomedCT | 256051006, 322154000, 372871004, 8372007 |
LNC | LP15006-7, MTHU001492 |
English | Promethazine, 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, Promethazine [nausea], Promethazine [nausea] [see c8i..], Proazamine, Prometazin, Promethazine [Chemical/Ingredient], prometazin, Promethazine [nausea] [see c8i..] (product), promethazine, PROMETHAZINE, Diprazinum, Promethazine product, Promethazine (product), Promethazine (substance), Promethazine [dup] (substance), Promethazine [nausea] [see c8i..] (substance) |
Swedish | Prometazin |
Czech | promethazin |
Finnish | Prometatsiini |
Russian | PROZAMIN, PROMETAZIN, TIAZINAMII, METILPROMETAZIN, МЕТИЛПРОМЕТАЗИН, ПРОЗАМИН, ПРОМЕТАЗИН, ТИАЗИНАМИЙ |
Japanese | ヒベルナ, メチレンジサルチル酸プロメタジン, プロザミン, プロメタジン塩酸塩, ピレチア, フェネルガン, 塩酸プロメタジン, イソプロメタジン, プロメタジン |
Spanish | prometazina (sustancia), prometazina [náuseas] [ver c8i..] (producto), prometazina [náuseas] [ver c8i..], Fenergan, prometacina (sustancia), prometacina, prometazina (producto), prometazina, Proazamina, Prometazina |
Polish | Prometazyna, Difergan, Fenergan |
Portuguese | Fenergan, Proazamina, Prometazina |
French | Prométhazine |
German | Proazamin, Promethazin |
Italian | Prometazina |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Phenergan (C0591971) |
|
---|---|
Definition (CHV) | brand name of an allergy medicine |
Definition (CHV) | brand name of an allergy medicine |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D011398 |
English | Phenargan, phenergan, phenergan [brand name], Phenergan |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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