Gastroenterology Book

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Promethazine

Aka: Promethazine, Phenergan
  1. Indications
    1. Nausea or Vomiting
    2. Motion Sickness or Vertigo
      1. Other agents are preferred (e.g. Dimenhydrinate)
  2. Mechanism
    1. Phenothiazine Antiemetic
  3. Contraindications
    1. Do not use under age 2 years
  4. Adverse Effects
    1. Excessive sedation
    2. Respiratory Depression
      1. Apnea and death have occurred in children
  5. Precautions
    1. Long plasma Half-Life (observe prior to discharge)
    2. Lowers Seizure threshold
    3. Avoid use in children (absolutely contraindicated <2yo)
  6. Dosing
    1. Precautions: IV dosing used but not FDA labeled
    2. Adults: 12.5 to 25 mg PO/IM/PR q4-6 hours
    3. Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours
      1. Maximum: 25 mg per dose
  7. Efficacy
    1. Less effective Antiemetic than Prochlorperazine (Compazine) in ER patients
      1. Ernst (2000) Ann Emerg Med 36(2): 89-94 [PubMed]
    2. Sedation may delay Emergency Department discharge
  8. References
    1. Johnson (1993) Harriet Lane, Mosby, p. 521
    2. (2002) Tarascon Pocket Pharmacopoeia, p. 67
Medication Costs
Promethazine DM syrup (on 6/18/2017 at Walmart.com)
Promethazine DM syrup #120 ml for $4.00 $0.03 each
Promethazine DM syrup #360 ml for $10.00 $0.03 each
Promethazine (on 6/18/2017 at Walmart.com)
Promethazine 25mg #12 tablets for $4.00 $0.33 each
Promethazine 25mg #36 tablets for $10.00 $0.28 each
Promethazine plain syrup (on 6/18/2017 at Walmart.com)
Promethazine plain syrup #180 ml for $4.00 $0.02 each
Promethazine plain syrup #540 ml for $10.00 $0.02 each
promethazine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
PROMETHAZINE 12.5 MG SUPPOS Generic $7.67 each
PROMETHAZINE 12.5 MG TABLET Generic $0.09 each
PROMETHAZINE 25 MG SUPPOSITORY Generic $7.23 each
PROMETHAZINE 25 MG TABLET Generic $0.06 each
PROMETHAZINE 25 MG/ML AMPUL Generic $1.31 per ml
PROMETHAZINE 25 MG/ML VIAL Generic $1.21 per ml
PROMETHAZINE 50 MG SUPPOSITORY Generic $31.00 each
PROMETHAZINE 50 MG TABLET Generic $0.18 each
PROMETHAZINE 6.25 MG/5 ML SYRP Generic $0.02 per ml
PROMETHAZINE VC SYRUP Generic $0.21 per ml
PROMETHAZINE VC-CODEINE SYRUP Generic $0.39 per ml
PROMETHAZINE-CODEINE SYRUP Generic $0.03 per ml
PROMETHAZINE-DM SOLUTION Generic $0.01 per ml
PROMETHAZINE-DM SYRUP Generic $0.02 per ml
PROMETHAZINE-PE-CODEINE SYRUP Generic $0.39 per ml
PROMETHAZINE-PHENYLEPHRINE SYR Generic $0.21 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Promethazine (C0033405)

Definition (CHV) a drug used to treat allergy symptoms
Definition (CHV) a drug used to treat allergy symptoms
Definition (NCI) A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.
Definition (MSH) A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011398
SnomedCT 256051006, 322154000, 372871004, 8372007
LNC LP15006-7, MTHU001492
English Promethazine, 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, Promethazine [nausea], Promethazine [nausea] [see c8i..], Proazamine, Prometazin, Promethazine [Chemical/Ingredient], prometazin, Promethazine [nausea] [see c8i..] (product), promethazine, PROMETHAZINE, Diprazinum, Promethazine product, Promethazine (product), Promethazine (substance), Promethazine [dup] (substance), Promethazine [nausea] [see c8i..] (substance)
Swedish Prometazin
Czech promethazin
Finnish Prometatsiini
Russian PROZAMIN, PROMETAZIN, TIAZINAMII, METILPROMETAZIN, МЕТИЛПРОМЕТАЗИН, ПРОЗАМИН, ПРОМЕТАЗИН, ТИАЗИНАМИЙ
Japanese ヒベルナ, メチレンジサルチル酸プロメタジン, プロザミン, プロメタジン塩酸塩, ピレチア, フェネルガン, 塩酸プロメタジン, イソプロメタジン, プロメタジン
Spanish prometazina (sustancia), prometazina [náuseas] [ver c8i..] (producto), prometazina [náuseas] [ver c8i..], Fenergan, prometacina (sustancia), prometacina, prometazina (producto), prometazina, Proazamina, Prometazina
Polish Prometazyna, Difergan, Fenergan
Portuguese Fenergan, Proazamina, Prometazina
French Prométhazine
German Proazamin, Promethazin
Italian Prometazina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Phenergan (C0591971)

Definition (CHV) brand name of an allergy medicine
Definition (CHV) brand name of an allergy medicine
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011398
English Phenargan, phenergan, phenergan [brand name], Phenergan
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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