//fpnotebook.com/
Prochlorperazine
Aka: Prochlorperazine, Compazine
- Indications
- Nausea or Vomiting
- Migraine Headache
- Motion Sickness
- Vertigo
- Hiccups
- Mechanism
- Phenothiazine Antiemetic
- Dopamine 2 Antagonist
- Adverse effects
- Orthostatic Hypotension
- Extrapyramidal Reaction
- Precaution
- Reactions may be delayed up to 2 weeks after dose
- Reactions
- Akathisia (25-60% after single dose)
- Dystonic Reaction (4% after a single dose)
- Olsen (2000) Am J Emerg Med 18(5): 609-11 +PMID:10999579 [PubMed]
- Drotts (1999) Ann Emerg Med 34(4 Pt 1): 469-75 [PubMed]
- Concurrent Diphenhydramine (Benadryl) prevents Akathisia (NNT 5, ARR 22%)
- Diphenhydramine (Benadryl) 50 mg IV (adults) was the dose used in study
- Vinson (2001) Ann Emerg Med 37(2):125-31 +PMID:11174228 [PubMed]
- Dosing
- Adults
- Compazine 5-10 mg PO/IV/IM q6-8 hours
- Compazine 25 mg PR q12 hours
- Sustained release Compazine 15 mg PO qam or 10 mg bid
- Children (over age 2 years or >10 kg)
- Compazine 0.1 mg/kg/dose PO/PR q6-8 hours
- Compazine 0.1 to 0.15 mg IM q6-8 hours
- Precautions
- IV dosing must be administered over 2 minutes or more
- Lowers Seizure threshold
- Efficacy
- Better Antiemetic than Phenergan in ER patients
- Ernst (2000) Ann Emerg Med 36(2): 89-94 [PubMed]
- References
- Johnson (1993) Harriet Lane, Mosby, p. 521
- (2002) Tarascon Pocket Pharmacopoeia, p. 67
- Olsen (2000) Am J Emerg Med 18(5):609-11 [PubMed]
- Vinson (2001) Ann Emerg Med 37(2):125-31 [PubMed]