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Misoprostol
Aka: Misoprostol, Cytotec, PGE1 Gel
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Mechanism
- Gastric Mucosa Protection by prostaglandin replacement
- Preparations
- Misoprostol (Cytotec)
- Indication
- Peptic Ulcer Disease prevention
- Prevents ulcers in those on NSAIDs chronically
- Cervical Ripening agent in Pregnancy Labor Induction
- Dosing
- See Cervical Ripening for pregnancy dosing
- Option 1: 100 ug qid with food
- Option 2: 200 ug bid with food
- Better tolerated than qid dosing
- Side Effects
- Diarrhea
- Poorly tolerated
- Efficacy: Peptic Ulcer Disease reduction
- Dosing qid: 4% Peptic Ulcer Disease recurrence
- Dosing bid: 8% Peptic Ulcer Disease recurrence
- Placebo: 16% Peptic Ulcer Disease recurrence
- Reference
- Raskin (1995) Ann Intern Med 123:344-50 [PubMed]