Gastroenterology Book



Aka: Lactulose
  1. See Also
    1. Laxative
    2. Osmotic Laxative
    3. Constipation
    4. Functional Constipation
    5. Pediatric Constipation
  2. Mechanism
    1. Converts Ammonia to unabsorbed Ammonium
    2. Produces Diarrhea
    3. Alters bowel flora
  3. Indications
    1. Hepatic Encephalopathy (in Cirrhosis)
    2. Constipation
  4. Advantages
    1. Poorly absorbed (may be used in Renal Failure)
  5. Disadvantages: Constipation
    1. Not as effective or well tolerated as Miralax
  6. Dosages
    1. Constipation
      1. Lactulose (Chronulac)
        1. Consider Sorbitol 70% as alternative agent
        2. Adults: 30 ml PO qhs
        3. Children (10 mg/15 ml) 1-3 cc/kg/day divided qd-bid
          1. Easier to administer to young children
        4. May cause abdominal cramping and Flatus
      2. Lactitol
        1. As effective as Lactulose with less pain and Flatus
        2. Pitzalis (1995) Pediatr Med Chir 17(3):223-6 [PubMed]
    2. Hepatic Encephalopathy
      1. Initial: 30-50 ml PO qh until Diarrhea
      2. Next: 15-30 ml PO tid-qid prn 2-3 stools/day
    3. Hepatic Coma
      1. Lactulose 300 ml in 700 ml water retention enema
Medication Costs
Lactulose syrup (on 6/18/2017 at
Lactulose syrup #236 ml for $4.00 $0.02 each
Lactulose syrup #708 ml for $10.00 $0.01 each
lactulose (on 4/19/2017 at Medicaid.Gov Pharmacy Drug pricing)
LACTULOSE 10 GM/15 ML SOLUTION Generic $0.01 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Lactulose (C0022957)

Definition (NCI) A disaccharide (sugar) synthesized from fructose and galactose, Lactulose is used to treat constipation and some liver diseases. Nondigestible in mammals, lactulose passes unabsorbed down to the large intestine where resident bacteria consume it and produce lactic, acetic, and formic acids, which draw fluid into the bowel to soften the stool (laxative effect). Acidification of the colon contents attracts ammonia from the bloodstream, assisting stool excretion; helpful in liver failure when ammonia cannot be detoxified. (NCI04)
Definition (MSH) A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
Concepts Pharmacologic Substance (T121) , Carbohydrate (T118)
MSH D007792
SnomedCT 111137007, 273945008
LNC LP61647-1, LP173648-9
English Lactulose, D-Fructose, 4-O-beta-D-galactopyranosyl-, lactulose, lactulose (medication), laxatives lactulose, LACTULOSE, 4-O-beta-D-Galactopyranosyl-D-fructofuranose, Lactulose [Chemical/Ingredient], Lactulose product, Lactulose (product), Lactulose (substance)
Swedish Laktulos
Czech laktulosa
Finnish Laktuloosi
Polish Laktuloza
Japanese ラクツロース, ピアーレ, モニラック, ラグノス
Spanish lactulosa (producto), lactulosa (sustancia), lactulosa, Lactulosa
French Lactulose
German Lactulose
Italian Lattulosio
Portuguese Lactulose
Derived from the NIH UMLS (Unified Medical Language System)

You are currently viewing the original '\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree