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Hepatitis A Immunoglobulin
Aka: Hepatitis A Immunoglobulin, Hepatitis A Ig
- See Also
- Hepatitis A
- Hepatitis A Vaccine
- Indications (otherwise administer Hepatitis A Vaccine)
- Preexposure Travel to endemic areas
- Travel within 1 month (otherwise use Vaccine)
- Age under 1 year or Vaccine otherwise contraindicated
- Postexposure (within 2 weeks of exposure)
- Household and institutional contacts
- Not necessary for casual work contacts
- Epidemiology
- Most frequent Vaccine preventable disease in travelers
- Protocol
- Pre-exposure for travelers to endemic areas
- Travel <3 months
- Hepatitis A Immunoglobulin 0.02 ml/kg IM
- Travel Longer than 3 months (protective for 5 months)
- Hepatitis A Immunoglobulin 0.06 ml/kg IM q4 months
- Post-exposure (within 2 weeks)
- Hepatitis A Immunoglobulin 0.02 ml/kg IM
- Preparation
- Immunoglobulin from pooled human plasma
- Considered safe from transmission of contagious disease
- Viruses inactivated
- Tested for Hepatitis B, Hepatitis C and HIV
- Contraindications
- IgA Deficiency
- Not contraindicated in pregnancy or Lactation
- Efficacy
- Pre-exposure before travel
- Prevents infection in up to 85%
- Post-exposure (if given within 2 weeks of exposure)
- Prevents infection in up to 89%
-
Drug Interactions: Live Attenuated Vaccines
- Immunoglobulin decreases immunogenicity
- Delay MMR for 3 months after Immunoglobulin
- Delay Varicella Vaccine for 5 months after Ig
- References
- Bianco (2004) Dig Liver Dis 36:834-42 [PubMed]
- Craig (2004) N Engl J Med 350:476-81 [PubMed]