Gastroenterology Book


Autoimmune Pancreatitis

Aka: Autoimmune Pancreatitis
  1. Epidemiology
    1. Uncommon cause of Chronic Pancreatitis
    2. Average age: 63 years (More than 80% are over age 50 years)
    3. Male gender predominance by 2 fold
  2. Symptoms: Presentations
    1. Jaundice (>60%)
    2. Abdominal Pain (>30%)
  3. Associated Conditions
    1. Sjogren's Syndrome
    2. Rheumatoid Arthritis
    3. Inflammatory Bowel Disease
  4. Diagnosis
    1. IgG4 titer
      1. Significantly increased in Autoimmune Pancreatitis
    2. CT Abdomen
      1. Diffuse pancreatitic involvement
  5. Management
    1. Prednisone 40 mg/day for 1 week and then taper dose down by 5 mg weekly
  6. References
    1. Finkelberg (2006) N Engl J Med 355: 2670-2676 [PubMed]

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