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Liver Function Test
Aka: Liver Function Test, LFT
- See Also
- Liver Function Test Abnormality
- Labs: Markers of liver function and protein synthesis
- Serum Albumin
- Serum Bilirubin
- Prothrombin Time
- Labs: Markers of hepatocellular disease
- Alanine Aminotransferase (ALT)
- Most specific for hepatocyte injury
- Aspartate Aminotransferase (AST)
- Less specific than ALT (present outside liver)
- AST to ALT ratio
- Most liver conditions (e.g. NASH): Ratio <1
- Alcoholism: Ratio >2
- Wilson's Disease >4
- Lactate Dehydrogenase (LDH)
- Least specific for hepatocyte injury
- Dramatically increased in ischemic hepatitis
- Increased with alk phos in liver metastases
- Labs: Markers of cholestasis
- Alkaline Phosphatase
- Gamma glutamyl transferase (GGT)
- Serum Bilirubin
- Labs: Disease specific markers
- Definite value
- Viral Hepatitis Serology
- Iron studies
- Ceruloplasmin (Wilson's Disease)
- Limited value: Anti-Smooth Muscle Ab
- Antimitochondrial Antibody
- Alpha-1 antitrypsin