Gastroenterology Book

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Lactose Breath Hydrogen Test

Aka: Lactose Breath Hydrogen Test
  1. See Also
    1. Lactose Intolerance
    2. Lactose Tolerance Test
  2. Indications
    1. Lactose Intolerance testing
  3. Efficacy
    1. Preferred over Lactose Tolerance Test
    2. Test Sensitivity: 90%
  4. Technique
    1. Measure baseline breath hydrogen concentration
    2. Patient ingests lactose
      1. Classic: 25 to 50 grams lactose
      2. Physiologic: 12 grams lactose (same as in 8 oz milk)
    3. Measure breath hydrogen concentration in 3 to 8 hours
      1. Increase >20 ppm suggests Lactose Intolerance
  5. False negative causes
    1. Gastrointestinal flora absent (e.g. recent antibiotics)
  6. False positive causes
    1. Recent Exercise
    2. Aspirin use
    3. Tobacco smoking
  7. References
    1. Powell in Goldman (2000) Cecil Medicine, p. 711

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