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Helicobacter pylori Stool Antigen
Aka: Helicobacter pylori Stool Antigen, H. pylori Stool Antigen, HpSA
- See Also
- Helicobacter pylori Noninvasive Testing
- Indications
- Dyspepsia evaluation
- Confirmation of cure after H. pylori management
- Mechanism
- Measures H. pyloriAntigen present in stool sample
- Efficacy
- Stool monoclonal Antigen tests (enzyme immunoassay)
- Test Sensitivity: 92%
- Test Specificity: 94%
- Most accurate, but more expensive than immunochromatography
- Stool monoclonal Antigen tests (Immunochromatography)
- Test Sensitivity: 69-87%
- Test Specificity: 87-93%
- Variable reliability, but available for office based testing
- Accurate for confirmation of cure at 7 days
- Antigen levels significantly suppressed with cure
- Vaira (2002) Ann Intern Med 136:280-7 [PubMed]
- Protocol: Patient stops medications 2 weeks before test
- Stop Proton Pump Inhibitors (but less affected than Urea Breath Test)
- Stop all antibiotics
- Stop bismuth compounds (e.g. Pepto Bismol)
- Advantages
- Excellent first line non-invasive test for diagnosis
- Noninvasive test of H. pylori cure
- Inexpensive
- References
- Calvet (2009) Clin Infect Dis 48(10): 1385-91 +PMID:19368506 [PubMed]
- Cutler AF (1995) Gastroenterology 109:136-41 +PMID:7540995 [PubMed]