//fpnotebook.com/
Helicobacter pylori Noninvasive Testing
Aka: Helicobacter pylori Noninvasive Testing, H. pylori IgG, H. pylori Serology, H. pylori ELISA
- See Also
- Urea Breath Test
- H. pylori Stool Antigens (HpSA)
- Indications
- Dyspepsia evaluation
- Labs: First-Line Helicobacter Pylori tests
- Urea Breath Test
- Test Sensitivity: 97%
- Test Specificity: 100%
- Requires Fasting for 6 hours, no PPI for 2 weeks before test, and expensive
- Stool monoclonal Antigen tests (enzyme immunoassay)
- Test Sensitivity: 92%
- Test Specificity: 94%
- Most accurate, but more expensive than immunochromatography
- Stool monoclonal Antigen tests (Immunochromatography)
- Test Sensitivity: 69-87%
- Test Specificity: 87-93%
- Variable reliability, but available for office based testing
- Labs: Other Helicobacter PyloriAntibody or Antigen testing
- IgG testing may be positive for years after eradication
- Indicated only for initial diagnosis
- Not used to confirm H. pylori cure
- Reference lab Serology (ELISA for H. pylori IgG)
- Test Sensitivity: 90-93%
- Test Specificity: 95-96%
- Office-based lab whole blood Serology (ELISA for IgG)
- Test Sensitivity: 50-85%
- Test Specificity: 75-100%
- Urine ELISA for H. pylori IgG
- Test Sensitivity: 70-96%
- Test Specificity: 77-85%
- SalivaELISA for H. pylori IgG
- Test Sensitivity: 82-91%
- Test Specificity: 71-85%
- Other Testing: String Test
- Mechanism
- Polymer string is swallowed
- String is recovered and run for PCR or culture
- Accuracy
- Test Sensitivity: 75-80%
- Test Specificity: 75-100%
- Advantages
- Noninvasive procedure
- Disadvantages
- Tests do not confirm cure after H. pylori management
- Cure confirmation is only by the following tests
- Urea Breath Test
- H. pylori Stool Antigen (HpSA)
- Endoscopic Biopsy for H. pylori
- References
- Calvet (2009) Clin Infect Dis 48(10): 1385-91 +PMID:19368506 [PubMed]
- Hahn (2000) Gastrointest Endosc 52(1):20-6 [PubMed]
- Ho (2000) Gastroenterol Clin North Am 29(4):853-62 [PubMed]
- Meurer (2002) Am Fam Physician 65(7):1327-39 [PubMed]
- Snyder (1999) Can J Gastroenterol 13:585-9 [PubMed]