Gastroenterology Book


Fecal Calprotectin

Aka: Fecal Calprotectin
  1. Indications
    1. Suspected Inflammatory Bowel Disease
  2. Mechanism
    1. Indicator of fecal Leukocyte activity
  3. Protocol
    1. Calprotectin is stable in stool samples at room Temperature for up to 1 week
  4. Interpretation
    1. Negative test suggests diagnoses other than Inflammatory Bowel Disease are more likely
    2. Positive test requires Colonoscopy for confirmation
  5. Efficacy: Diagnosis of Inflammatory Bowel Disease
    1. Test Sensitivity: 93%
    2. Test Specificity
      1. Adults: 96%
      2. Children and Adolescents: 76%
  6. References
    1. Schoepfer (2010) Am J Gastroenterol 105(1): 162-9 [PubMed]
    2. van Rheenen (2010) BMJ 341:c3369 [PubMed]

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