Gastroenterology Book


Maddrey Discriminant Function

Aka: Maddrey Discriminant Function
  1. Indications
    1. Acute Alcoholic Hepatitis Prognosis
  2. Calculation
    1. Discriminant function = 4.6 x (PTa - PTc) + Bili
    2. Where
      1. PTa: Actual ProTime (PT) in seconds
      2. PTc: Normal ProTime (PT) in seconds (typically 11-13 s)
      3. Bili: Serum Bilirubin in mg/dl
  3. Interpretation
    1. Discriminant result >32 is associated with severe disease and a 1 month mortality >50%

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