Gastroenterology Book



Aka: Hepatomegaly, Liver Enlargement, Hepatosplenomegaly
  1. See Also
    1. Hepatomegaly in Newborns
    2. Splenomegaly
  2. Causes: Hepatomegaly
    1. Liver displacement (Palpable liver, no Hepatomegaly)
      1. Obstructive Lung Disease (Asthma, COPD)
      2. Adjacent mass (Cholecystitis, abscess)
      3. Thin patient
    2. Infectious
      1. AIDS
      2. Hepatic Abscess (e.g. Amebiasis)
      3. Relapsing Fever
      4. Echinococcal cysts
      5. Schistosomiasis
      6. Kala Azar
    3. Hepatitis
      1. Alcoholic Hepatitis
      2. Autoimmune Hepatitis
      3. Viral Hepatitis
    4. Congestive Hepatomegaly (often precedes edema)
      1. Congestive Heart Failure (systemic venous congestion)
      2. Constrictive Pericarditis
      3. Tricuspid stenosis
    5. Miscellaneous
      1. Wilson's Disease
      2. Fatty Liver
      3. Cirrhosis
      4. Hemochromatosis
      5. Primary Sclerosing Cholangitis
      6. Cholestasis
      7. Mixed cryoglobulinemia
      8. Congenital hepatic fibrosis
      9. Polycystic liver disease
      10. Hurler's Syndrome
      11. Gaucher's Disease
      12. Sarcoidosis
      13. Amyloidosis
    6. Malignancy
      1. Intraabdominal malignancy
      2. Pancreatic Cancer
      3. Hepatocellular Carcinoma
    7. Medication toxicity
      1. See Hepatotoxins
      2. NRTI (e.g. Stavudine)
  3. Causes: Hepatosplenomegaly
    1. See Splenomegaly
    2. Babesiosis
    3. Chaga's Disease
    4. Mononucleosis
    5. Malaria
    6. Beta Thalassemia Major
    7. Essential-mixed cryoglobulinemia
    8. Viral Arthritis (e.g. Parvovirus)
    9. Severe congestive Hepatomegaly (see Hepatomegaly)
    10. Acute Lymphoblastic Leukemia
    11. Mast Cell disorders (Mastocytosis)
  4. Evaluation
    1. Step 1: Confirm Liver Enlargement versus displacement
    2. Step 2: Check Serum AST and Serum ALT
      1. If positive then go to step 3
      2. If negative then go to step 4
    3. Step 3: Check for Viral Hepatitis
    4. Step 4: Check Abdominal CT for Liver Lesion
    5. Step 5: Consider congestive Hepatomegaly (e.g. CHF)
    6. Step 6: Consider liver biopsy

Hepatomegaly (C0019209)

Definition (MSHCZE) Zvětšení jater. Může mít řadu příčin (hepatitida, nádor, městnání krve při srdečním selhávání, ukládání tuku – steatóza aj.). Zvětšená játra lze vyhmatat při vyšetření břicha, jejich zvětšení dobře prokáže ultrazvuk. (cit. Velký lékařský slovník online, 2013 )
Definition (NCI_NCI-GLOSS) Enlarged liver.
Definition (NCI) Abnormal enlargement of the liver.
Definition (MSH) Enlargement of the liver.
Concepts Sign or Symptom (T184)
MSH D006529
ICD9 789.1
ICD10 R16.0
SnomedCT 207231001, 207233003, 207232008, 158515001, 158513008, 158514002, 80515008
English Hepatomegaly, HEPATOMEGALY, LIVER ENLARGEMENT, Liver enlargement, [D]Hepatomegaly (context-dependent category), [D]Hepatomegaly NOS (context-dependent category), [D]Liver enlargement (context-dependent category), [D]Hepatomegaly, [D]Hepatomegaly NOS, [D]Liver enlargement, liver enlargement, hepatic enlargement, enlarged liver, hepatomegaly (physical finding), hepatomegaly, Enlarged Liver, Liver, Enlarged, Hepatomegaly NOS, Hepatomegaly [Disease/Finding], enlargement of liver, Enlarged;liver, large liver, enlarged livers, [D]Hepatomegaly NOS (situation), [D]Hepatomegaly (situation), [D]Liver enlargement (situation), Liver enlarged, Large liver, Large liver (disorder), enlargement; liver, liver; enlargement, Enlargement of liver
French HEPATOMEGALIE, AUGMENTATION DU VOLUME DU FOIE, Hépatomégalie, Hypertrophie du foie, Hypertrophie hépatique
Portuguese HEPATOMEGALIA, Aumento de volume do fígado, AUMENTO DE VOLUME DO FIGADO, Fígado Hipertrófico, Hepatomegalia, Fígado Aumentado
Spanish HEPATOMEGALIA, hígado grande, Aumento de tamaño del hígado, [D]hepatomegalia, SAI (categoría dependiente del contexto), [D]agrandamiento del hígado (categoría dependiente del contexto), [D]hepatomegalia (categoría dependiente del contexto), HIGADO AUMENTADO DE TAMANO, [D]hepatomegalia, SAI (situación), [D]hepatomegalia, SAI, [D]agrandamiento del hígado, [D]hepatomegalia, [D]hepatomegalia (situación), [D]agrandamiento del hígado (situación), hepatomegalia (trastorno), hepatomegalia, Hepatomegalia, Hígado Agrandado
German HEPATOMEGALIE, Lebervergroesserung, LEBERVERGROESSERUNG, Hepatomegalie, Lebervergrößerung
Dutch leververgroting, lever; vergroting, vergroting; lever, hepatomegalie, Hepatomegalie, Vergrote lever
Swedish Leverförstoring
Japanese カンシュダイ, 肝腫, 肝腫脹, 肝腫大, 肝臓腫大
Czech hepatomegalie, Hepatomegalie, Zvětšení jater, zvětšení jater
Finnish Hepatomegalia
Italian Fegato ingrossato, Epatomegalia
Polish Hepatomegalia, Powiększenie wątroby
Hungarian Májmegnagyobbodás, Hepatomegalia
Norwegian Forstørret lever, Hepatomegali
Derived from the NIH UMLS (Unified Medical Language System)

Hepatosplenomegaly (C0019214)

Definition (NCI) An abnormal enlargement of both the liver and spleen.
Concepts Sign or Symptom (T184)
ICD10 R16.2
SnomedCT 36760000
LNC LA21228-4
English HEPATOSPLENOMEGALY, Hepatosplenomegaly NOS, hepatosplenomegaly, Hepatosplenomegaly, Hepatosplenomegaly (disorder)
Italian Allargamento del fegato e della milza, Epatosplenomegalia NAS
Dutch hepatosplenomegalie NAO, hepatosplenomegalie
French Hépatosplénomégalie SAI, HEPATOSPLENOMEGALIE, Hépatosplénomégalie
German Hepatosplenomegalie NNB, HEPATOSPLENOMEGALIE, Hepatosplenomegalie
Portuguese Hepatosplenomegalia NE, HEPATOSPLENOMEGALIA, Hepatosplenomegalia
Spanish Hepatoesplenomegalia NEOM, HEPATOESPLENOMEGALIA, hepatoesplenomegalia (trastorno), hepatoesplenomegalia, Hepatoesplenomegalia
Japanese 肝脾腫大NOS, 肝脾腫大, カンヒシュダイ, カンヒシュダイNOS
Czech Hepatosplenomegalie, Hepatosplenomegalie NOS
Hungarian Hepatosplenomegalia k.m.n., Hepatosplenomegalia
Derived from the NIH UMLS (Unified Medical Language System)

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