Gastroenterology Book

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Fibrosis Probability Score

Aka: Fibrosis Probability Score, FIB-4 Index
  1. Indications
    1. Hepatitis B risk for fibrosis
    2. Nonalcoholic Fatty Liver Disease assessment for Fibrosis (NASH)
  2. Criteria
    1. Score = (Age x AST) / (

      x sqrRoot(ALT))

  3. Interpretation
    1. Score <1.45: Good Negative Predictive Value (80% for Hepatitis CVirus related fibrosis)
    2. Score >3.25 (>2.67 in NAFLD): Positive Predictive Value >80%
  4. Efficacy
    1. Test Sensitivity: 85%
    2. Test Specificity: 65%
  5. References
    1. Mallet (2009) Aliment Pharmacol Ther 15;29(4):409-15 +PMID: 19035983 [PubMed]

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