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Floppy Iris Syndrome
Aka: Floppy Iris Syndrome
- See Also
- Cataract Extraction
- Pathophysiology: Intraoperative Floppy Iris Syndrome
- Sudden prolapse and Pupil Constriction in Cataract surgery
- Related to Alpha Adrenergic Antagonist medications
- Causes
- Specific Alpha-1 adrenergic antagonists (highest risk)
- Tamsulosin (Flomax)
- Non-specific Alpha Adrenergic Antagonists
- Terazosin (Hytrin)
- Doxazosin (Cardura)
- Prazosin (Minipress)
- Beta Blockers with Alpha Adrenergic Antagonist activity
- Carvedilol (Coreg)
- Labetalol (Trandate)
- Other agents with alpha-adrenergic antagonist activity
- Risperidone
- Clorpromazine
- Imipramine
- Complications
- Tamsulosin (Flomax) increases the complication risk most significantly (as much as 2.3 times)
- Complications include
- Retinal Detachment
- Lost lens fragment
- Severe iris defects
- Prevention
- Identify preoperative Cataract patients with any current or prior history of Alpha Adrenergic Antagonist use (even distant use)
- Notify the ophthalmologist performing the procedure of this medication use
- Surgical procedure can be proactively modified for patients on alpha-1 antagonists
- References
- (2012) Presc Lett 19(5): 28
- Chang (2008) J Cataract Refract Surg 34(12): 2153-62 [PubMed]
- Bell (2009) JAMA 301(19): 1991-6 [PubMed]