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Intraocular Sympathomimetic
Aka: Intraocular Sympathomimetic, Dipivefrin, Propine, Intraocular Epinephrine- Indication
- Adjunct to Open Angle Glaucoma therapy
- Mechanism: Intraocular Epinephrine
- Decreases aqueous outflow resistance
- Decreases aqueous production
- Preparations
- Dipivefrin (Propine) 1 drop bid
- Adverse Effects (If absorbed)
- Tachypnea
- Tachycardia
- Hypertension
- Tremor
- Restlessness
- Headache
Dipivefrin (C0058415) |
|
|---|---|
| Definition (NCI) | An ester prodrug of epinephrine, with sympathomimetic activity. Due to its lipophilicity, dipivefrin penetrates more easily to the anterior chamber of the eye and is hydrolyzed to epinephrine, when applied locally. Epinephrine, an adrenergic agonist, enhances the outflow of aqueous humor and decreases the production of aqueous humor by vasoconstriction. The overall result is a reduction in intraocular pressure. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C015173 |
| SnomedCT | 73647000, 37013008, 372830005 |
| English | dipivaloylepinephrine, dipivalyl epinephrine, dipivefrin, Propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, (+-)-, DPE - Dipivefrin, adrenaline dipivalate, dipivefrin [Chemical/Ingredient], DPE, DPE - dipivalyl epinephrine, dipivefrine, Dipivalyl epinephrine, Dipivefrine, Dipivalyl adrenaline, Dipivefrin (product), Dipivefrin (substance), Dipivefrin, DIPIVEFRIN |
| Spanish | dipivalil epinefrina, dipivefrina (producto), dipivefrina (sustancia), dipivefrina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Propine (C0138647) |
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|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C015173 |
| English | Propine, propine, Propine brand, Diopine, Allergan brand of dipivefrin hydrochloride |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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