Ophthalmology Book

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Intraocular Carbonic Anhydrase Inhibitor

Aka: Intraocular Carbonic Anhydrase Inhibitor, Dorzolamide, Trusopt, Brinzolamide, Azopt
  1. Indication
    1. Open Angle Glaucoma
    2. Patients unable to tolerate Beta Blocker or as adjunct
  2. Mechanism
    1. Inhibits bicarbonate formation in the ciliary body
    2. Results in decreased aqueous production
  3. Preparations
    1. Topical
      1. Dorzolamide (Trusopt) 2%, 1 drop three times daily
      2. Brinzolamide (Azopt) 1%, 1 drop three times daily
        1. Available as combination with Brimonidine (Simbrinza)
    2. Systemic
      1. Acetazolamide (Diamox)
      2. Methazolamide (Neptazane)
  4. Efficacy
    1. Less effective than Intraocular Beta Blocker and Intraocular Prostaglandin
  5. Adverse Effects
    1. Topical is well tolerated (contrast with oral)
      1. May cause bitter taste
    2. Systemic
      1. Paresthesias in hands and face
      2. Malaise, Anorexia, and severe weight loss
      3. Hypokalemia
      4. Nephrolithiasis
  6. Reference
    1. (1995) Med Lett Drugs Ther 37:(956):76-77 [PubMed]
Medication Costs
dorzolamide (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
DORZOLAMIDE HCL 2% EYE DROPS Generic $1.10 per ml
DORZOLAMIDE-TIMOLOL EYE DROPS Generic $0.90 per ml
azopt (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing)
AZOPT 1% EYE DROPS $24.98 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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