Ophthalmology Book


Intraocular Alpha-2 Adrenergic Agonist

Aka: Intraocular Alpha-2 Adrenergic Agonist, Intraocular Alpha-Adrenergic, Apraclonidine, Lopidine, Brimonidine, Alphagan, Lumify, Mirvaso
  1. See Also
    1. Open Angle Glaucoma
  2. Preparations
    1. Apraclonidine (Lopidine)
    2. Brimonidine (Alphagan)
      1. Available as combination with Brinzolamide (Simbrinza)
      2. Mirvaso (Brimonidine gel)
        1. Indicated for Eye Redness due to Rosacea
      3. Lumify (OTC Brimonidine 0.025%) released in 2018
        1. Marketed as OTC to reduce Eye Redness
        2. No proof that it is more effective than OTC ocular Decongestants (e.g. visine) and more expensive
        3. Evaluate Eye Redness for underlying cause instead
        4. (2018) presc lett 25(6): 35 [PubMed]
  3. Mechanism
    1. Decrease Aqueous Humor production
  4. Drug Interactions
    1. Monoamine Oxidase Inhibitors
  5. Adverse Effects
    1. Eye itching
  6. Efficacy
    1. Less effective than Intraocular Beta Blocker and Intraocular Prostaglandin
Medication Costs
apraclonidine (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing)
APRACLONIDINE HCL 0.5% DROPS Generic $10.86 per ml
brimonidine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
BRIMONIDINE 0.2% EYE DROP Generic $0.76 per ml
BRIMONIDINE TARTRATE 0.15% DRP Generic $19.56 per ml
alphagan (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing)
ALPHAGAN P 0.1% DROPS $25.67 per ml
ALPHAGAN P 0.15% EYE DROPS Generic $19.56 per ml
mirvaso (on 4/1/2017 at Medicaid.Gov Pharmacy Drug pricing)
MIRVASO 0.33% GEL $14.01 per gram
MIRVASO 0.33% GEL PUMP $13.77 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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