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Liothyronine
Aka: Liothyronine, Cytomel, Triiodothyronine Replacement, T3 Replacement- Indications
- Not generally recommended (no proven benefit and associated risk)
- Adjunct to Levothyroxine in Hypothyroidism
- Lethargy or memory deficits despite normal TSH
- Adverse Effects
- Risk of cardiovascular risks when combined with Levothyroxine
- Efficacy
- May improve neuropsychiatric symptoms
- Changes after replacing T3 and T4
- Improved mood and energy
- Decreased confusion, fear, and irritability
- No difference in TSH normalization
- Studies suggests no benefit
- Dosing (with Thyroxine dosing)
- Start: 1:14 ratio of Liothyronine to Levothyroxine (e.g. 5 mcg Liothyronine to 75 mcg Levothyroxine)
- Typical: 12.5 to 25 mcg orally daily
- Maximum: 100 ug orally daily
- References
- (2017) Presc Lett 25(1): 4
- Bunevicius (1999) N Engl J Med 340:424 [PubMed]
| Medication Costs | ||
|---|---|---|
| liothyronine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| LIOTHYRONINE SOD 25 MCG TAB | Generic | $0.53 each |
| LIOTHYRONINE SOD 5 MCG TAB | Generic | $0.36 each |
| LIOTHYRONINE SOD 50 MCG TAB | Generic | $0.89 each |
| cytomel (on 6/1/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CYTOMEL 25 MCG TABLET | Generic | $0.53 each |
| CYTOMEL 5 MCG TABLET | Generic | $0.36 each |
| CYTOMEL 50 MCG TABLET | Generic | $0.89 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Cytomel (C0010826) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D014284 |
| French | Cytomel |
| English | cytomel, Cytomel |
| Norwegian | Cytomel |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Triiodothyronine (C0041014) |
|
|---|---|
| Definition (NCI) | A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity. |
| Definition (NCI) | A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04) |
| Definition (NCI_NCI-GLOSS) | A thyroid hormone. |
| Definition (MSH) | A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. |
| Definition (CSP) | one of the thyroid hormones; an organic iodine containing compound secreted in small amounts by the thyroid gland; most circulating triiodothyroinine is produced by the deiodination of thyroxine in the peripheral tissues. |
| Definition (PDQ) | A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=470233&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=470233&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C907" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116) |
| MSH | D014284 |
| SnomedCT | 61275002, 350358003, 74495008, 36437009 |
| CPT | 1011720 |
| LNC | LP15922-5, MTHU003701 |
| English | Liothyronine, Triiodothyronine, triiodothyronine, L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, 3,3',5-triiodo-L-thyronine, T3, T<sub>3</sub>, L-triiodothyronine preparation, T>3< preparation, T<sub>3</sub> preparation, T3 preparation, therapeutic triiodothyronine, L-Triiodothyronine, T AAA THYROID HORMONE 003, Triiodothyronine [Chemical/Ingredient], t3 thyroid hormone, t3, LIOTHYRONINE, T3 Thyroid Hormone, Thyroid Hormone, T3, Triiodothyronine preparation, Triiodothyronine preparation (product), Triiodothyronine T3, T-3, liothyronine, 3,5,3' Triiodothyronine, T3 - Liothyronine, Tri-iodothyronine product, T3 - Triiodothyronine, Total triiodothyronine, T>3<, Liothyronine (product), Triiodothyronine (substance), Liothyronine (substance), Triiodothyronine preparation (substance), Therapeutic T3 |
| Swedish | Trijodtyronin |
| Spanish | liotironina, liotironina (producto), preparado con triyodotironina, tri-iodotironina, producto (producto), tri-iodotironina, producto, preparado de T3, preparado de T<sub>3</sub>, preparado con T>3<, preparado de L-triyodotironina, preparado con triyodotironina (producto), preparado con T3, preparado con T<sub>3</sub>, T3, 3, 5, 3' triyodotironina, preparado de T>3<, preparado de triyodotironina (producto), preparado de triyodotironina (sustancia), preparado de triyodotironina, tri-iodotironina, producto (sustancia), triyodotironina (sustancia), triyodotironina, Triyodotironina, Hormona Tiroidea T3, Liotironina |
| Czech | hormon T3, trijodthyronin |
| Finnish | Trijodotyroniini |
| French | T3 (Hormone thyroïdienne), Tri-iodothyronine, Hormone thyroïdienne T3, Triiodothyronine, 3,5,3'-triiodothyronine, Liothyronine |
| Russian | TRIIODTIRONIN, LIOTIRONIN, ЛИОТИРОНИН, ТРИИОДТИРОНИН |
| Japanese | リオチロニン, フリーT3, リオサイロニン, トリヨードチロニン, トリヨードサイロニン, L-トリヨードチロニン |
| German | T AAA SCHILDDRÜSENHORMON 003, Liothyronin, Triiodthyronin, T3-Schilddrüsenhormon |
| Croatian | TRIJODTIRONIN |
| Polish | Trójjodotyronina, T3, Trijodotyronina |
| Norwegian | Liotyronine, Trijodtyronin, T3 thyreoideahormon |
| Portuguese | Tri-Iodotironina, Hormônio T3 da Tireoide, T3, Hormônio Tireóideo T3, Liotironina |
| Italian | Triiodotironina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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