Endocrinology Book

Adrenal Disease

Diabetes Mellitus

Growth Disorders

Geriatric Medicine

Hypoglycemic Disorders

Obesity

Pituitary Disease

Thyroid Disease

Sexual Development

Obstetrics Chapter related topics

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Growth Hormone Replacement

Aka: Growth Hormone Replacement, hGH, Somatropin, Recombinant Human Growth Hormone
  1. See Also
    1. Growth Hormone
  2. Indications
    1. Medical Uses
      1. Used to enhance growth in Short Stature
    2. Illicit uses
      1. Ergogenic Aid used by athletes
      2. Similar effect as with Anabolic Steroids
        1. Difficult to detect
        2. Expensive (>$1000/month)
  3. Preparations
    1. Initially derived from cadavers in 1950's
      1. Transmitted Creutzfeldt-Jakob Disease to patients
    2. Now produced by recombinant Genetics
      1. Genentech developed Somatrem (Protropin) in 1990s
  4. Dosing
    1. Available only via injection
  5. Adverse Effects
    1. Growth-Hormone induced Myopathy
      1. Muscles hypertrophy, but are weaker than before
    2. Acromegaly
    3. Diabetes Mellitus
    4. Cardiomyopathy
    5. Congestive Heart Failure
    6. May be related to Leukemia development

Somatropin (C0169964)

Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D019382
SnomedCT 395883003, 325831003, 325892008, 129495007
English Biosynthetic human growth horm, HGH - Growth hormone, Somatropin, somatropin, Somatotrophin, Human growth hormone, GH - Growth hormone, Somatotropic hormone, Growth hormone, SOMATROPIN, Somatropin [2] (product), Somatropin [2], Biosynthetic human growth hormone, Somatropin (product), Somatropin (substance), Somatropin [2] (substance)
Spanish hormona de crecimiento, somatotrofina, hormona somatotrófica, somatropina (2), somatropina (2) (producto), somatropina (producto), somatropina (sustancia), somatropina
Czech somatropin (lidský), lidský růstový hormon, somatotropin (lidský)
Finnish Ihmisen kasvuhormoni
French Somatotropine humaine, Somatropine humaine, Hormone de croissance humaine, hGH (Human Growth Hormone)
Italian Somatotropina (umana), Somatropina (umana), Somatropina, Ormone della crescita umano, hGH (ormone della crescita umano)
Russian GORMON ROSTA CHELOVEKA, ROSTA GORMON METIONILOVYI CHELOVEKA, SOMATOTROPIN CHELOVEKA, SOMATROPIN, ROSTA GORMON CHELOVEKA, METIONILOVYI GORMON ROSTA CHELOVEKA, SOMATREM, ГОРМОН РОСТА ЧЕЛОВЕКА, МЕТИОНИЛОВЫЙ ГОРМОН РОСТА ЧЕЛОВЕКА, РОСТА ГОРМОН МЕТИОНИЛОВЫЙ ЧЕЛОВЕКА, СОМАТОТРОПИН ЧЕЛОВЕКА, СОМАТРЕМ, СОМАТРОПИН
Japanese ソマトトロピン(ヒト), ソマトトロピン-ヒト, ヒト成長ホルモン, ソマトロピン, 成長ホルモン-ヒト
Croatian HORMON RASTA, HUMANI, HUMANI HORMON RASTA
Polish Ludzki hormon wzrostu, Somatropina, HGH, Somatotropina (ludzka)
Norwegian Veksthormon, humant, Humant veksthormon, Somatropin (humant), hGH (human veksthormon), Somatropin
German Humanes Wachstumshormon, Somatotropin (humanes), Somatropin, HGH (Humanes Wachstumshormon), Somatropin (humanes)
Portuguese Somatotropina (Humana), Somatropina (Humana), Hormônio do Crescimento Humano
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Recombinant Human Growth Hormone (C0384570)

Definition (MSH) Mammalian-cell derived recombinant human growth hormone.
Definition (PDQ) A recombinant form of endogenous human growth hormone (GH), a polypeptide produced by the anterior lobe of the human pituitary gland. GH exhibits growth-promoting effects and metabolic effects on carbohydrate, fat, protein and bone metabolism. GH stimulates protein synthesis and the uptake of amino acids into cells, and induces lipolysis in adipose tissues. The secretion of GH increases with sexual maturation and then declines steadily. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=456264&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=456264&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C837" NCI Thesaurus)
Concepts Hormone (T125) , Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH D019382
SnomedCT 31696009, 126193008
English r-hGH(m), rhGH, recombinant human growth hormone, Recombinant Human Growth Hormones, Recombinant Human Growth Hormones [Chemical/Ingredient], Recombinant Human Growth Hormone, hghr, hGHr, Human growth hormone recombinant, Human growth hormone recombinant (product), r-hGH-M, Human growth hormone recombinant preparation (product), Human growth hormone recombinant preparation, Human growth hormone recombinant (substance), Human growth hormone recombinant preparation (substance), Recombinant Human Growth Hormone (Mammalian)
German Rekombinantes humanes Wachstumshormon (Säugetiere), r-hGH(m), r-hGH-M
Italian r-hGH(m), r-hGH-M, Ormone della crescita umano ricombinante (mammiferi)
Norwegian r-hGH(m), Rekombinant humant veksthormon (pattedyr-), r-hGH-M
Spanish somatotropina humana biotecnológica (producto), somatotropina humana biotecnológica, STH recombinante, somatotrofina humana recombinante, preparado de somatotrofina humana biotecnológica, preparado de somatotropina humana biotecnológica (producto), preparado de somatotropina humana biotecnológica (sustancia), preparado de somatotropina humana biotecnológica, somatotropina humana biotecnológica (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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