Endocrinology Book


Corticosteroid Associated Osteoporosis

Aka: Corticosteroid Associated Osteoporosis, Osteoporosis Secondary to Corticosteroid Use
  1. See Also
    1. Systemic Corticosteroid
    2. Osteoporosis
  2. Risk Factors: Osteoporosis on long-term Corticosteroids
    1. Prednisone 1-5 mg: Relative Risk 1.9x
    2. Prednisone 5-10 mg: Relative Risk 4.5x
    3. Prednisone >10 mg: Relative Risk 32x
  3. Evaluation: Obtain Bone Mineral Density
    1. Check BMD at baseline prior to therapy
    2. Check BMD every 6-12 months during first 2 years
  4. Prevention: Osteoporosis from long-term steroids
    1. Use lowest dose of a short-acting glucocorticoid
    2. Maintain a well-balanced, low Sodium diet (2-3 gram)
    3. Weight bearing Exercise and Isometric Exercise
    4. Calcium Supplementation 1500 mg/day
    5. Vitamin D Supplementation 400-800 IU/day
    6. Control Hypercalciuria with Thiazide Diuretics
    7. Treat Hypogonadism
      1. Menopause: Hormone Replacement Therapy
      2. Men with low testosterone: Testosterone Replacement
    8. Treat bone loss if it occurs with Corticosteroid use
      1. Hormone Replacement Therapy
      2. Bisphosphonates
      3. Calcitonin
  5. References
    1. Dubois (2002) Chest 121:1456-63 [PubMed]
    2. Lane (1998) Endocrinol Metab Clin North Am 27:465-83 [PubMed]

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree