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Obesity
Aka: Obesity, Overweight
- See Also
- Obesity in Children
- Obesity Evaluation
- Obesity Measurement (or Obesity Screening)
- Obesity Risk (or Obesity Comorbid Conditions)
- Obesity Management
- Obesity Medication
- Dietary Supplements in Obesity
- Exercise in Obesity
- Obesity Resources
- Epidemiology
- Prevalence: 33% US adults age 20 to 74 are obese
- Trends
- Obesity Prevalence has increased 8% since 1980
- Obesity Prevalence has increased 54% ages 6-11 years
- Patients gain 1 pound per year after age 25
- Pathophysiology: Fat expands in 2 ways
- Fat Cell Number
- Fat cell number does not decrease with weight loss
- Increases 5 fold until age 22 years
- Increase continues with nutritional excess
- Non-obese person has 25-30 billion fat cells
- Obese person has 260 billion cells
- Fat Cell Size
- Fat cell size reduces with weight loss
- Adults fill existing fat cells when they over eat
- Evaluation
- See Obesity Evaluation
- See Obesity Measurement
- See Obesity Risk
- Diagnosis: Obesity
- Men: 20% over estimated Ideal Weight
- Women: 30% over estimated Ideal Weight
- Management
- See Obesity Management
- See Obesity Medications
- See Obesity Resources
- Worksheets
- Dietician in the Box
- PreventEdWeightLoss2Sjm.htm
- Research: Obesity Gene (ob)
- Ob expression
- Feeding turns on rat adipocytes via Insulin
- Inhibit Neuropeptide Y synthesis at appetite center
- Neuropeptide Y
- Decreases thermogenesis
- Increases Insulin and appetite
- Ob gene function: Produces Leptin (protein)
- Leptin uppresses appetite in rats
- Leptin increases thermogenesis in rats
- Leptin decreases Insulin levels in rats
- References
- Saladin (1995) Nature 377:527-9 [PubMed]
- Stephens (1995) Nature 377:530-2 [PubMed]
- Pelleymounter (1995) Science, 269(5223):540-3 [PubMed]