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Thyroxine-Binding Globulin
Aka: Thyroxine-Binding Globulin, Thyroxine Binding Globulin, Thyroid Binding Globulin, TBG
- See Also
- Thyroid Function Test
- Thyroid Function Summary
- Triiodothyronine ( Free T3)
- Thyroxine (Free T4)
- Thyroid Stimulating Hormone (TSH)
- Free Thyroxine Index (Free T4 Index)
- Thyroid Releasing Hormone (TRH)
- Antithyroid Antibody
- Thyroxine Replacement
- Hypothyroidism
- Hyperthyroidism
- Hypothyroidism in Pregnancy
- Thyroid Dysfunction in Pregnancy
- Physiology
- Radioimmunoassay of major storage of Thyroid Hormone
- TBG binds Thyroid Hormone in circulation
- Thyroxine (T4) is 99.97% protein bound
- Triiodothyronine (T3) is 99.7% protein bound
- Interpretation: General
- TBG effects measurement of total T4 and T3
- Increased TBG increases total T4 and T3 measurements
- Decreased percent Free T4 and T3
- No change in Free T4 and Free T3
- Decreased TBG decreases total T4 and T3 measurements
- Increased percent Free T4 and T3
- No change in Free T4 and Free T3
- Labs unaffected by Thyroid Binding Globulin (TBG)
- Free Thyroxine Index (FTI)
- Calculation based on T3 Resin Uptake
- Free Thyroxine (Free T4)
- Free Triiodothyronine (Free T3)
- Interpretation: Increased TBG (Reduces total T4 and T3 measurements)
- Pregnancy
- Newborn state
- Chronic Active Hepatitis
- Biliary Cirrhosis
- Infection
- Acute intermittent porphyria
- Familial hyperthyroxinemia
- Drugs
- Oral Contraceptives
- Estrogens
- Tamoxifen
- Methadone
- Heroin
- Perphenazine
- Interpretation: Decreased TBG (Elevates total T4 and T3 measurements)
- Chronic Liver Disease
- Obstructive Jaundice or Cirrhosis
- Severe systemic illness
- Active Acromegaly
- Nephrotic Syndrome
- Surgical Stress
- Medications
- Androgens
- Salicylates
- L-asparaginase
- Large doses of Glucocorticoids (Prednisone)