Endocrinology Book

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Luteinizing Hormone

Aka: Luteinizing Hormone, Lutropin, Pituitary Interstitial Cell Stimulating Hormone, Pituitary Luteinizing Hormone, Serum LH, Urine LH, Ovulation Kit
  1. See Also
    1. Follicle Stimulating Hormone (FSH)
  2. Physiology
    1. Luteinizing Hormone (LH) is a glycoprotein secreted by Basophil cells in the anterior Pituitary Gland
      1. Stimulation (releasing factors)
        1. Hypothalamic Gonadotrophic Releasing Hormone (GnRH)
      2. Inhibition (negative feedback loop to Hypothalamus and Pituitary Gland)
        1. Testosterone (Males)
        2. Estrogen
        3. Progesterone
        4. Inhibin
          1. Produced by corpus luteum in women
          2. Produced by spermatogenesis in men (suppresses FSH, but not LH in males)
    2. Luteinizing Hormone (LH) effects in women
      1. Stimulates ovarian follicles to ovulate and mature into a corpus luteum
      2. Corpus luteum in turn secretes Estrogen and Progesterone
      3. Functions in concert with FSH which stimulates ovarian follicle growth and Estradiol secretion
    3. Luteinizing Hormone (LH) effects in men
      1. Stimulates Leydig Cells within Testes to produce Testosterone
      2. Functions in concert with FSH which stimulates spermatogenesis and maturation within Sertoli Cells
  3. Labs: Normal Serum Levels
    1. Male: <15 mIU/ml
    2. Female: <30 mIU/ml (higher in mid-cycle surge)
    3. Menopause: 30 to 200 mIU/ml
  4. Labs: Urine LH
    1. Urine LH dip-stick kit used to detect Ovulation
    2. Urine LH consistently surges 72 hours BEFORE Ovulation
      1. Identifies 2 days in cycle most likely to conceive
      2. Start testing a few days before expected Ovulation
    3. As of 2022, Urine LH kits are accurate and cost effective (as low as $40 for 50 tests)
      1. Examples: OvuQuick, Clearblue Easy Ovulation
  5. References
    1. Stewart (2003) AAFP Board Review, Seattle
    2. (2022) Presc Lett 29(2): 10-1
    3. Guermandi (2001) Obstet Gynecol 97:92-6 [PubMed]

Luteinizing Hormone (C0023607)

Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (CHV) a hormone that regulates steroid production by the TESTIS and the OVARY
Definition (MSH) A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Definition (CSP) major gonadotropin secreted by the adenohypophysis; luteinizing hormone regulates steroid production by the interstitial cells of the gonads; the preovulatory luteinizing hormone surge in females induces ovulation and subsequent luteinization of the follicle.
Concepts Hormone (T125) , Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH D007986
SnomedCT 85681004, 259348009, 64182005
LNC LP14683-4, LP32099-1, LP32698-0, MTHU001767
English Hormone, Interstitial Cell-Stimulating, Hormone, Luteinizing, Interstitial Cell Stimulating Hormone, Interstitial Cell-Stimulating Hormone, Luteinizing Hormone, Lutropin, interstitial cell-stimulating hormone, LH - Luteinising hormone, LH - Luteinizing hormone, ICSH (interstitial cell stimulating hormone), Luteinizing Hormone [Chemical/Ingredient], luteinising hormone, lutropin, leuteinizing hormone, luteinizing hormone (LH), icsh, interstitial cell stimulating hormone, LUTEINIZING HORMONE, Luteinizing hormone (substance), Pituitary interstitial cell stimulating hormone (substance), ICSH (Interstitial Cell Stimulating Hormone), LH (Luteinizing Hormone), luteinizing hormone, ICSH, LH, Luteotropin, Luteinizing hormone, Luteinising hormone, Pituitary interstitial cell stimulating hormone, Pituitary luteinizing hormone, Pituitary luteinising hormone, Pituitary luteinizing hormone (substance), Pituitary interstitial cell stimulating hormone -RETIRED-
Swedish LH
Czech hormon stimulující intersticiální buňky, luteinizační hormon, LH (luteinizační hormon), ICSH (hormon stimulující intersticiální buňky), lutropin
Finnish Lutropiini
French Hormone stimulant les cellules interstitielles, LH (Luteinizing hormone), Lutéotrophine, Lutéotropine, Lutropine, Gonadostimuline B, Hormone gonadotrope B, Hormone lutéinisante, Hormone lutéinostimulante
Russian LIUTEINIZIRUIUSHCHII GORMON, LIUTROPIN, LG, IKSG, INTERSTITSIAL'NYE KLETKI-STIMULIRUIUSHCHII GORMON, ИКСГ, ИНТЕРСТИЦИАЛЬНЫЕ КЛЕТКИ-СТИМУЛИРУЮЩИЙ ГОРМОН, ЛГ, ЛЮТЕИНИЗИРУЮЩИЙ ГОРМОН, ЛЮТРОПИН
German ICSH, LH, Luteinisierendes Hormon, Lutropin, ICSH (Interstitialzellen-stimulierendes Hormon), Interstitialzellen-stimulierendes Hormon, LH (Luteinisierendes Hormon)
Polish Hormon luteinizujący, Lutropina, LH
Japanese 黄体化ホルモン, 黄体形成ホルモン, ルトロピン, 間質細胞刺激ホルモン
Norwegian ICSH, Luteiniserende hormon, Interstitiecelle stimuerende hormon, LH
Spanish hormona hipofisaria estimulante de las células intersticiales - RETIRADO -, hormona hipofisaria estimulante de las células intersticiales - RETIRADO - (concepto no activo), Hormona Estimulante de Célula Intersticial, hormona hipofisaria estimulante de las células intersticiales del ovario, hormona hipofisaria luteinizante (sustancia), hormona hipofisaria luteinizante, hormona luteinizante, luteotrofina, luteotropina, HL (Hormona Luteinizante), Hormona Luteinizante, Lutropina, Hormona Estimulante de las Células Intersticiales, ICSH (Hormona Estimulante de las Células Intersticiales)
Portuguese Hormônio Estimulador das Células Intersticiais, Hormônio Estimulante de Célula Intersticial, Lutropina, Hormônio Estimulante das Células Intersticiais, Hormônio Luteinizante, ICSH (Hormônio Estimulante das Células Intersticiais), LH (Hormônio Luteinizante)
Italian Ormone luteinizzante
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Urine luteinizing hormone measurement (C0474669)

Concepts Laboratory Procedure (T059)
SnomedCT 144615005, 167381004
English Urine luteinising hormone level (procedure), Urine LH titer, Urine LH titre, Urine luteinising hormone level, Urine luteinizing hormone level, Urine luteinising hormone measurement, Urine luteinizing hormone measurement (procedure), Urine luteinizing hormone measurement
Spanish determinación de nivel urinario de LH, determinación de nivel urinario de hormona luteinizante, determinación de título urinario de LH, determinación de título urinario de hormona luteinizante, medición urinaria de LH, medición urinaria de hormona luteinizante (procedimiento), medición urinaria de hormona luteinizante
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Serum LH measurement (C1304771)

Concepts Laboratory Procedure (T059)
SnomedCT 143725000, 166372004, 143762003, 166417002, 273969007
English Serum LH measurement, serum lutropin level, serum luteinizing hormone measurement, serum luteinizing hormone measurement (lab test), Luteinising hormone - L.H., Luteinizing hormone (& serum level), Luteinizing hormone, Luteinising hormone (& serum level) (procedure), Serum luteinising hormone lev, L.H. level, Serum luteinising hormone level, Luteinizing hormone - L.H., Luteinising hormone, Luteinising hormone (& serum level), LH - Luteinizing hormone, Serum luteinizing hormone level, Serum luteinizing hormone lev, Serum LH level (procedure), LH - Luteinising hormone, Serum luteinizing hormone measurement (procedure), Serum luteinizing hormone measurement, Serum LH measurement (procedure), Serum LH Test, Serum LH level
Spanish determinación de nivel sérico de LH, determinación de nivel sérico de hormona luteinizante, medición sérica de LH, medición sérica de hormina luteinizante (procedimiento), medición sérica de hormina luteinizante
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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