Endocrinology Book


Free Urine Cortisol

Aka: Free Urine Cortisol, 24-hour Urinary free cortisol level, 24 hour Urine Cortisol, Urine 17-Ketosteroid excretion, Urine 17-Hydroxysteroid excretion
  1. Indication
    1. Screening for Cushing's Disease
  2. Interpretation: Normal
    1. Free Urine Cortisol: 10-84 mcg/24 hours (up to 110 mcg/24 hours in some reference ranges)
  3. Interpretation: Increased (especially if 4x normal range)
    1. See Serum Cortisol
    2. Cushing's Disease
    3. ACTH-Secreting Pituitary Adenoma
    4. Estrogen
  4. Precautions
    1. Depends on complete and accurate urine collection

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