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Gastrointestinal Manifestations of Diabetes Mellitus
Aka: Gastrointestinal Manifestations of Diabetes Mellitus, Diabetes Related Gastrointestinal Conditions
- See Also
- Diabetes Mellitus Complications
- Gastroparesis
- Nonalcoholic Fatty Liver Disease
- Diabetes Related Intestinal Enteropathy
- Associated Conditions: Esophagus, Stomach and Bowel
- Gastroparesis
- Diabetes Related Intestinal Enteropathy
- Esophageal Dysmotility
- Increased Incidence with longer standing Diabetes Mellitus (Type I or Type II)
- Esophageal Reflux
- Mechanism: Esophageal Dysmotility, decreased lower esophageal sphincter tone, prolonged transit time
- Celiac Disease (Gluten Sensitive Enteropathy)
- Increased association with Type I Diabetes Mellitus (5-10 fold increased risk)
- Pancreatitis
- Increased risk (esp. with complications)
- More common in new onset Diabetes Mellitus
- Pancreatic Cancer
- Seen more often at the time of new onset Diabetes Mellitus diagnosis
- Associated Conditions: Liver
- Nonalcoholic Fatty Liver Disease
- Hepatitis C
- Higher rate of Diabetes Mellitus development
- Comorbid Diabetes Mellitus and Hepatitis C increases risk of fibrosis, Cirrhosis and Hepatocellular Carcinoma
- Hepatitis B
- Increased risk if sharing needles and lancets
- Hepatitis B Vaccine recommended
- Diabetic Hepatopathy
- Hepatocytes are overwhelmed with glycogen in uncontrolled Diabetes Mellitus Type I
- Uncontrolled Type I Diabetes Mellitus may present as Acute Hepatitis
- Hemochromatosis (Bronze Diabetes)
- Diabetes Mellitus is one component of the Hemochromatosis triad
- Cirrhosis
- Common pathway for the more severe manifestations of liver disease in Diabetes Mellitus
- Prevention
- Optimize Glucose control
- See Specific Conditions for management
- References
- Careyva (2016) Am Fam Physician 94(12): 980-6 [PubMed]