Emergency Medicine Book

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Trichothecene Mycotoxin

Aka: Trichothecene Mycotoxin, T2 toxin, Trichothecene
  1. See Also
    1. Mycotoxin
  2. Pathophysiology
    1. Agent
      1. Trichothecene Mycotoxins
        1. Produced by filamentous fungi (molds)
      2. Inactivation
        1. Extremely stable in heat and UV light
        2. Destruction requires heating 1500 F for 30 minutes
        3. Brief exposure to sodium Hypochlorite inactivates
    2. Transmission
      1. Used as aerosolized Biological Weapon
        1. Laos, Kampuchea, Afghanistan in late 1970's
      2. Aerosol: "yellow rain" drops of yellow fluid
  3. Symptoms and signs
    1. Skin
      1. Local pain
      2. Pruritus
      3. Skin redness
      4. Vesicles
      5. Skin necrosis and sloughing
    2. Respiratory
      1. Nose and throat pain
      2. Nasal Discharge
      3. Itching and sneezing
      4. Cough
      5. Dyspnea
      6. Wheezing
      7. Chest Pain
      8. Hemoptysis
    3. Severe systemic
      1. Prostration
      2. Weakness
      3. Ataxia
      4. Collapse
      5. Shock
      6. Death
  4. Differential Diagnosis
    1. Mustard agents
    2. Staphylococcal Enterotoxin B
    3. Ricin
  5. Management
    1. Activated Charcoal for ingestion
  6. Prevention
    1. No Vaccine or antitoxin available
    2. Decontamination

T-2 Toxin (C0039185)

Definition (CSP) potent mycotoxin produced in feedstuffs by some Fusarium species.
Definition (MSH) A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.
Concepts Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D013605
SnomedCT 39979007
English Fusariotoxin, Fusaritoxin, T 2 Toxin, T-2 Toxin, T2 Toxin, Toxin, T-2, Toxin, T2, Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-, T AA TOXIN 02, T-2 Toxin [Chemical/Ingredient], t 2 toxins, t-2 toxin, t2 mycotoxin, T-2 fungal toxin, T-2 toxin, T-2 fungal toxin (substance), T2 toxin, Mycotoxin T2
French Toxine T-2, Toxine T2, Fusariotoxine T-2, Mycotoxine T-2
Swedish T-2-toxin
Czech T-2 toxin
Finnish T-2-toksiini
Russian FUZARITOKSIN, T-2 TOKSIN, T-2 ТОКСИН, ФУЗАРИТОКСИН
Italian Tossina T2, Fusariotossina, Tossina T-2
German T AA TOXIN 02, Fusaritoxin, T-2-Toxin
Polish Toksyna-2
Japanese フザリトキシン, T-2トキシン
Spanish toxina T-2, toxina fúngica T-2 (sustancia), toxina fúngica T-2, micotoxina T-2 (sustancia), micotoxina T-2, Fusartoxina, Toxina T-2
Portuguese Fusaritoxina, Toxina T-2
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Trichothecenes (C0040952)

Definition (MSH) Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.
Concepts Biologically Active Substance (T123) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D014255
SnomedCT 693002
LNC LP64676-7
English Trichothecenes, Trichothecenes [Chemical/Ingredient], trichothecene, trichothecenes, Trichothecene, Fusarium toxins, Trichothecenes (substance), Fusarium toxins, NOS, Trichothecenes, NOS
Czech trichotheceny
Finnish Trikotekeenit
Russian TRIKHOTETSENEPOKSIDY, TRIKHOTETSENY, EPOKSITRIKHOTETSENY, ТРИХОТЕЦЕНЫ, ТРИХОТЕЦЕНЭПОКСИДЫ, ЭПОКСИТРИХОТЕЦЕНЫ
Japanese トリコテセンエポキシド, トリコテセン, エポキシトリコテセン
Swedish Trikotecener
Polish Trichoteceny
Spanish toxina de fusario, tricotecenos (sustancia), tricotecenos, Tricotecenos
French Trichothécènes
German Trichothecene
Italian Tricoteceni
Portuguese Tricotecenos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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