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Intranasal Drug Delivery Route
Aka: Intranasal Drug Delivery Route, Intranasal Medication Route, Intranasal Route of Medication Delivery
- See Also
- Procedural Sedation and Analgesia
- Indications
- Procedural Sedation and Analgesia
- Difficult Intravenous Access in Children
- Laceration Repair
- Lumbar Puncture
- Mechanism
- Nasal mucosa is well vascularized with rapid medication absorption
- Ideal intranasal medications are lipophilic and small in molecular size
- Intranasal medications are best tolerated and absorbed at pH 4.5 to 6.5
- Maximal amount that may be absorbed intranasally is 0.3 ml
- Typical drug delivery is via a Mucosal Atomization Device (MAD Atomizer)
- Device has 0.1 ml dead space (draw up extra 0.1 ml medication)
- Preparations: Intranasal medications for analgesia and sedation
- See Procedural Sedation and Analgesia for dosing
- Analgesia
- Fentanyl
- Ketamine
- Lidocaine
- Sedation
- Midazolam (Versed)
- Dexmedetomidine (Precedex)