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Topical Decongestant
Aka: Topical Decongestant, Spray Decongestant, Oxymetazoline, Intranasal Phenylephrine, Afrin, Intranasal Neo-Synephrine- See Also
- Indications
- Precautions
- Avoid using longer than 3 days
- Overuse results in Rhinitis Medicamentosa
- Avoid afrin (Oxymetazoline) in children (due to central alpha-2 agonist, Clonidine-like CNS depression)
- If a nasal Decongestant is used in children, Neo-Synephrine (Phenylephrine) is preferred
- Preparations
- Oxymetazoline (Afrin)
- Two sprays per nostril bid x2-3 days
- Phenylephrine (Neo-Synephrine)
- Adults: 2 sprays per nostril qid x2-3 days
- Child: Neo-Synephrine 1/8% q4-6 hours
- Oxymetazoline (Afrin)
Oxymetazoline (C0030071) |
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Definition (NCI) | An imidazole derivative with direct acting sympathomimetic activity. Oxymetazoline binds to and activates alpha-2 adrenergic receptors. Upon nasal or ocular administration, oxymetazoline constricts the arterioles in the nose and eye, resulting in decreased nasal and conjunctival congestion, respectively. |
Definition (MSH) | A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010109 |
SnomedCT | 29129004, 387158001 |
English | Oxymetazoline, Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, Oxymetazoline [Chemical/Ingredient], OXYMETAZOLINE, oxymetazoline, Oxymetazoline (product), Oxymetazoline (substance) |
Swedish | Oximetazolin |
Czech | oxymetazolin |
Finnish | Oksimetatsoliini |
Russian | OKSIMETAZOLIN, ОКСИМЕТАЗОЛИН |
Polish | Oksymetazolina |
Spanish | oximetazolina (producto), oximetazolina (sustancia), oximetazolina, Oximetazolina |
French | Oxymétazoline |
German | Oxymetazolin |
Italian | Ossimetazolina |
Portuguese | Oximetazolina |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Phenylephrine (C0031469) |
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Definition (MSH) | An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. |
Definition (NCI) | A direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output. |
Definition (CSP) | direct acting sympathomimetic amine that stimulates alpha-adrenergic receptors and is a powerful vasoconstrictor. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010656 |
SnomedCT | 372771005, 54765002 |
LNC | LP16252-6, MTHU007549 |
English | Phenylephrine, (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol, Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-, decongestants phenylephrine, phenylephrine (medication), Phenylephrine [Chemical/Ingredient], PHENYLEPHRINE, phenylephrine, Phenylephrine (product), Phenylephrine (substance) |
Swedish | Fenylefrin |
Czech | fenylefrin |
Finnish | Fenyyliefriini |
Russian | FENILEFRIN, MEZATON, METASIMPATOL, METASINEFRIN, NEOSINEFRIN, METOKSIDRIN, МЕЗАТОН, МЕТАСИМПАТОЛ, МЕТАСИНЕФРИН, МЕТОКСИДРИН, НЕОСИНЕФРИН, ФЕНИЛЭФРИН |
Japanese | フェニルエフリン, ネオシネフリン, フェニレフリン |
Polish | Metasympatol, Fenylefryna, Neosynefryna |
Spanish | fenilefrina (producto), fenilefrina (sustancia), fenilefrina, Fenilefrina |
French | Phényléphrine |
German | Phenylephrin |
Italian | Fenilefrina |
Portuguese | Fenilefrina |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Afrin (C0718291) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
English | Afrin, afrin |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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