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Sedating Antihistamine
Aka: Sedating Antihistamine, First Generation Antihistamine, Antihistamine, Chlorpheniramine, Bromopheniramine, Cyproheptadine, Hydroxyzine, Periactin, Atarax, Vistaril- See Also
- Mechanism
- First Generation Antihistamine
- Adverse Effects
- See Anticholinergic Toxicity
- Sedation or Paradoxic excitability
- Worsens Benign Prostatic Hyperplasia
- Worsens Glaucoma
- Dizziness
- Respiratory depression
- Tachycardia
- Seizures
- QT Prolongation (and Torsades de Pointes)
- Especially with Hydroxyzine
- Anticholinergic Symptoms
- Indications
- Allergic Rhinitis
- Antiemetic
- Anaphylaxis
- Acute Urticaria
- Chronic Urticaria
- Anti-pruritic
- Suppresses itching, and reduces lesions
- Does not completely eradicate
- Hydroxyzine (Atarax) is most potent Antihistamine for Pruritus
- Preparations: Antihistamine
- See Diphenhydramine (Benadryl)
- Chlorpheniramine (Chlor-Trimeton)
- Dose: 4 mg orally every 4 to 6 hours as needed
- Clemastine (Tavist)
- Dose: 1.34 mg orally twice daily as needed
- Cyproheptadine (Periactin)
- Dose: 4 mg orally three times daily as needed
- Hydroxyzine (Atarax, Vistaril)
- Dose: 0.5 mg/kg up to 25-50 mg orally or intramuscular every 4-6 hours as needed
| Medication Costs | ||
|---|---|---|
| chlorpheniramine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CHLORPHENIRAMINE ER 12 MG TAB | Generic OTC | $0.26 each |
| cyproheptadine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CYPROHEPTADINE 2 MG/5 ML SYRUP | Generic | $0.08 per ml |
| CYPROHEPTADINE 4 MG TABLET | Generic | $0.44 each |
| hydroxyzine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| HYDROXYZINE 10 MG/5 ML SOLN | Generic | $0.04 per ml |
| HYDROXYZINE 10 MG/5 ML SYRUP | Generic | $0.04 per ml |
| HYDROXYZINE HCL 10 MG TABLET | Generic | $0.07 each |
| HYDROXYZINE HCL 25 MG TABLET | Generic | $0.08 each |
| HYDROXYZINE HCL 50 MG TABLET | Generic | $0.10 each |
| HYDROXYZINE PAM 100 MG CAP | Generic | $0.45 each |
| HYDROXYZINE PAM 25 MG CAP | Generic | $0.06 each |
| HYDROXYZINE PAM 50 MG CAP | Generic | $0.08 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Chlorpheniramine (C0008281) |
|
|---|---|
| Definition (MSH) | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. |
| Definition (CSP) | histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, asthma and in veterinary applications; one of the most widely used of the classical antihistamines. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002744 |
| SnomedCT | 9944001, 372914003 |
| LNC | LP16072-8, MTHU006724 |
| English | Chlorphenamine, Chlorpheniramine, Chlorprophenpyridamine, 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, Chlorpheniramine (Allergy), chlorpheniramines (medication), chlorpheniramine (medication), chlorpheniramines, antihistamines chlorpheniramines, Chlorpheniramine [Chemical/Ingredient], CHLORPHENIRAMINE, 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine, Chlorophenylpyridamine, 4-Chloropheniramine, Chloropheniramine, chlorpheniramine, chlorphenamine, Chlorpheniramine (product), Chlorpheniramine (substance) |
| Swedish | Klorfeniramin |
| Czech | chlorfeniramin |
| Finnish | Kloorifeniramiini |
| Russian | KHLORFENAMIN, KHLORFENIRAMIN, KHLORPROFENPIRIDAMIN, ХЛОРПРОФЕНПИРИДАМИН, ХЛОРФЕНАМИН, ХЛОРФЕНИРАМИН |
| Japanese | クロルプロフェンピリダミン, マレイン酸クロルフェニラミン, クロルフェニラミン, クロルフェナミン |
| Italian | Clorprofenpiridamina, Clorofenamina, Clorofeniramina |
| Spanish | Clorfeniramina, Clorprofenpiridamina, Clorofeniramina, Cloroprofenpiridamina, clorfeniramina (producto), clorfeniramina (sustancia), clorfeniramina, Clorfenamina |
| Polish | Chlorfeniramina, Chlorfenamina |
| French | Chlorphénamine, Chlorphéniramine |
| German | Chlorphenamin, Chlorpheniramin, Chlorprophenpyridamin |
| Portuguese | Clorfenamina, Clorfeniramina, Clorprofempiridamina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cyproheptadine (C0010620) |
|
|---|---|
| Definition (NCI_NCI-GLOSS) | A drug that is used to treat asthma, allergies, and colds, and to relieve itching caused by certain skin disorders. It has also been used to stimulate appetite and weight gain, and is being studied in the treatment of weight loss caused by cancer and its treatment. Cyproheptadine belongs to the family of drugs called antihistamines. |
| Definition (MSH) | A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. |
| Definition (CSP) | serotonin antagonist and histamine H1 blocker used as an antipruritic, appetite stimulant, antiallergic, and to treat the post-gastrectomy dumping syndrome. |
| Definition (PDQ) | The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=315774&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=315774&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28949" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D003533 |
| SnomedCT | 26462003, 372683000 |
| LNC | LP18932-1, MTHU006211 |
| English | Cyproheptadine, cyproheptadine, Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, Cyproheptadine [Chemical/Ingredient], MK 141, 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine, 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene, CYPROHEPTADINE, cyproheptadine (medication), antihistamines cyproheptadine, Cyproheptadine (product), Cyproheptadine (substance) |
| Swedish | Cyproheptadin |
| Czech | cyproheptadin |
| Finnish | Syproheptadiini |
| Russian | TSIKLOGEPTADIN, PERITOL, ПЕРИТОЛ, ЦИКЛОГЕПТАДИН |
| Portuguese | Ciproeptadina, Ciproheptadina, Cipro-Heptadina |
| Polish | Cyproheptadyna |
| Japanese | シプロヘプタジン, 塩酸シプロヘプタジン |
| Spanish | ciproheptadina (producto), ciproheptadina (sustancia), ciproheptadina, Ciproheptadina |
| French | Cyproheptadine |
| German | Cyproheptadin |
| Italian | Ciproeptadina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Histamine H1 Antagonists (C0019592) |
|
|---|---|
| Definition (NCI) | Any agent that binds to the histamine H1 receptor, thereby antagonizing histamine mediated allergic reactions, such as bronchoconstriction, vasodilation and up-regulated capillary permeability. |
| Definition (NCI_NCI-GLOSS) | A type of drug that blocks the action of histamines, which can cause fever, itching, sneezing, a runny nose, and watery eyes. Antihistamines are used to prevent fevers in patients receiving blood transfusions and to treat allergies, coughs, and colds. |
| Definition (MSH) | Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D006634 |
| SnomedCT | 349955005, 373228009 |
| English | Antihistaminics, H1, H1 Antihistaminics, H1 Receptor Blockaders, Histamine H1 Receptor Blockaders, Receptor Blockaders, H1, Histamine H1 Receptor Antagonists, Antagonists, Histamine H1, Antagonists, Histamine H1 Receptor, Blockaders, Histamine H1 Receptor, H1 Antagonists, Histamine, Histamine H1 Blockers, Antihistamine, Histamine H1 Antagonists, HISTAMINE RECEPTOR ANTAGONISTS H1, BLOCKADERS HISTAMINE H1 RECEP, ANTIHISTAMINICS H 01, H1 RECEPT BLOCK, HISTAMINE H1 ANTAG, HISTAMINE H1 RECEPT ANTAG, HISTAMINE ANTAGONISTS H 001, RECEPT BLOCK H1, HISTAMINE H1 RECEPT BLOCK, HISTAMINE RECEPTOR BLOCKADERS H1, HISTAMINE H1 BLOCK, ANTAG HISTAMINE H1 RECEPT, ANTAG HISTAMINE H1, H1 blockers, histamine H1 receptor blockaders, antihistaminic h1, h1 antihistamine, h1 blockers, antihistamine h1, antihistamines h1, h1 blocker, antihistamine, H1 antihistamine, H1 antihistamine (product), H1 antihistamine (substance), H-1 Receptor Antagonist, Histamine-1 Receptor Antagonist |
| French | Antagonistes des récepteurs histaminergiques H1, Antihistamines H1, Antihistaminiques des récepteurs H1, Anti-histaminiques H1, Anti-histamines H1, Antihistaminiques H1, Antagonistes H1 |
| Swedish | Histamin H1-blockerare |
| Czech | histamin H1 - antagonisté, histaminové H1-receptory - blokátory |
| Finnish | Histamiini-H1-salpaajat |
| German | Antagonisten, Histamin H1-Rezeptor-, Antagonisten, Histamin H1-, Histamin-H1-Rezeptor-Antagonisten, Histamin-H1-Rezeptorblocker, H1-Rezeptorblocker, Histamin H1-Blocker, ANTIHISTAMINIKA H 01, HISTAMIN REZEPTORENBLOCKER H1, HISTAMIN REZEPTOREN ANTAGONISTEN H1, HISTAMIN ANTAGONISTEN H 001, Antihistaminika, H1-, Histamin-H1-Antagonisten |
| Russian | ANTIGISTAMINNYE H1 SREDSTVA, BLOKATORY GISTAMINOVYKH H1-RETSEPTOROV, GISTAMINA H1 ANTAGONISTY, ANTIGISTAMINNYE SREDSTVA, GISTAMINOVYKH H1-RETSEPTOROV ANTAGONISTY, GISTAMINOVYKH H1-RETSEPTOROV BLOKATORY, ANTIGISTAMINNYE SREDSTVA KLASSICHESKIE, PROTIVOGISTAMINNYE SREDSTVA, АНТИГИСТАМИННЫЕ H1 СРЕДСТВА, АНТИГИСТАМИННЫЕ СРЕДСТВА, АНТИГИСТАМИННЫЕ СРЕДСТВА КЛАССИЧЕСКИЕ, БЛОКАТОРЫ ГИСТАМИНОВЫХ H1-РЕЦЕПТОРОВ, ГИСТАМИНА H1 АНТАГОНИСТЫ, ГИСТАМИНОВЫХ H1-РЕЦЕПТОРОВ АНТАГОНИСТЫ, ГИСТАМИНОВЫХ H1-РЕЦЕПТОРОВ БЛОКАТОРЫ, ПРОТИВОГИСТАМИННЫЕ СРЕДСТВА |
| Japanese | 古典的抗ヒスタミン薬, ヒスタミンH1拮抗剤, ヒスタミンH1遮断薬, ヒスタミンH1受容体拮抗薬, ヒスタミンH1受容体遮断剤, 抗ヒスタミン剤H1, 古典的抗ヒスタミン剤, ヒスタミンH1受容器遮断薬, ヒスタミンH1アンタゴニスト, ヒスタミンH1受容体遮断薬, H1受容体拮抗薬, H1ブロッカー, H1受容体拮抗剤 |
| Croatian | HISTAMIN H1 ANTAGONISTI |
| Polish | Antagoniści histaminy H1, Leki przeciwhistaminowe H1, Antyhistaminiki H1, Leki antyhistaminowe H1, Blokery receptora H1 histaminy, Antyhistaminiki klasyczne |
| Portuguese | Bloqueadores dos Receptores Histamínicos H1, Antagonistas dos Receptores H1 de Histamina, Antagonistas dos Receptores Histamínicos H1, Bloqueadores dos Receptores H1 de Histamina, Anti-Histamínicos H1 |
| Spanish | Bloqueadores de los Receptores Histamínicos H1, Antagonistas de los Receptores Histamínicos H1, Bloqueadores de los Receptores H1 de Histamina, antihistamínico H1 (producto), antihistamínico H1 (sustancia), antihistamínico H1, Antagonistas del Receptor H1 de Histamina, Antihistamínicos H1 |
| Italian | Antagonisti dell'istamina H1 |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Hydroxyzine (C0020404) |
|
|---|---|
| Definition (CHV) | a kind of antihistamine and mild anti-anxiety drug |
| Definition (NCI) | A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. |
| Definition (MSH) | A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D006919 |
| SnomedCT | 372856003, 80165005 |
| LNC | LP15171-9, MTHU002560 |
| English | Hydroxyzine, 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol, Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, Hydroxyzine [Chemical/Ingredient], hydrOXYzine, HydrOXYzine, hydroxyzine, HYDROXYZINE, Hydroxyzine (product), Hydroxyzine (substance) |
| Swedish | Hydroxizin |
| Czech | hydroxyzin |
| Finnish | Hydroksitsiini |
| Russian | GIDROKSIZIN, ГИДРОКСИЗИН |
| Japanese | アタラックス-P, ヒドロキシジンパモ酸塩, パモ酸ヒドロキシジン, アタラックスP, ジスロンP, 塩酸ヒドロキシジン, ジスロン, アタラックス, ヒドロキシジン, ハタナジン, ヒドロキシジン塩酸塩 |
| Spanish | hidroxizina (sustancia), hidroxicina (producto), hidroxicina, hidroxizina, hidroxizina (producto), Hidroxizina, Hidroxicina, hidroxicina (sustancia) |
| Polish | Hydroksyzyna |
| French | Hydroxyzine |
| German | Hydroxyzin |
| Italian | Idrossizina |
| Portuguese | Hidroxizina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Periactin (C0031017) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D003533 |
| English | periactin, Periactin |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Atarax (C0684229) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D006919 |
| English | atarax, Atarax |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Vistaril (C0936278) |
|
|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D006919 |
| English | vistaril, Vistaril |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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