Otolaryngology Book



Aka: Aphthasol, Amlexanox
  1. Background
    1. Cost: $20/5g tube
  2. Indications
    1. Severe Aphthous Ulcers
  3. Mechanism: Reduces local inflammation
    1. Inhibits histamines
    2. Inhibits Leukotrienes
  4. Efficacy
    1. Speeds up ulcer healing by 1 day
  5. Dosing
    1. Apply 1/4 inch oral paste to ulcer after meals and qhs
    2. Start as soon as symptom onset
    3. Use until ulcer heals up to 10 days

amlexanox (C0103049)

Definition (NCI) An anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C045742
SnomedCT 108897008, 413507000
English 2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid, 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-, amlexanox, amoxanox, 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic Acid, 2-Amino-7-(1-methylethyl)-5-oxo-, amlexanox (medication), amlexanox [Chemical/Ingredient], 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic Acid, Amlexanox (substance), Amlexanox, Amlexanox (product), AMLEXANOX
Spanish amlexanox (sustancia), amlexanox, amlexanox (producto)
Derived from the NIH UMLS (Unified Medical Language System)

Aphthasol (C1097532)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C045742
English Aphthasol, GlaxoSmithKline brand of amlexanox
Derived from the NIH UMLS (Unified Medical Language System)

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