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Acute Generalized Exanthematous Pustulosis
Aka: Acute Generalized Exanthematous Pustulosis, AGEP
- See Also
- Life-Threatening Drug-Induced Rashes
- Adverse Drug Reaction
- Hypersensitivity Reaction
- Anaphylaxis
- Penicillin Allergy
- Gell and Coombs Classification
- Fixed Drug Eruption
- Pathophysiology
- Adverse Drug Reaction
- Symptoms
- Rash onset within four days of offending medication exposure
- Signs
- Fever
- Rash
- Onset at flexor surfaces (e.g. neck, axilla, antecubital fossa, popliteal fossa)
- Tiny, non-follicular Pustules
- Causes
- Beta-lactam antibiotics (Penicillins, Cephalosporins, carbapenems)
- Macrolide antibiotics (e.g. Erythromycin, Azithromycin)
- Calcium Channel Blockers
- Labs
- Complete Blood Count
- Leukocytosis
- Neutrophilia
- Management
- Eliminate the offending agent
- Consider Topical Corticosteroids
- References
- Jhun and DeClerck in Herbert (2015) EM:Rap 15(2): 9-11