Otolaryngology Book


Acute Generalized Exanthematous Pustulosis

Aka: Acute Generalized Exanthematous Pustulosis, AGEP
  1. See Also
    1. Life-Threatening Drug-Induced Rashes
    2. Adverse Drug Reaction
    3. Hypersensitivity Reaction
    4. Anaphylaxis
    5. Penicillin Allergy
    6. Gell and Coombs Classification
    7. Fixed Drug Eruption
  2. Pathophysiology
    1. Adverse Drug Reaction
  3. Symptoms
    1. Rash onset within four days of offending medication exposure
  4. Signs
    1. Fever
    2. Rash
      1. Onset at flexor surfaces (e.g. neck, axilla, antecubital fossa, popliteal fossa)
      2. Tiny, non-follicular Pustules
  5. Causes
    1. Beta-lactam antibiotics (Penicillins, Cephalosporins, carbapenems)
    2. Macrolide antibiotics (e.g. Erythromycin, Azithromycin)
    3. Calcium Channel Blockers
  6. Labs
    1. Complete Blood Count
      1. Leukocytosis
      2. Neutrophilia
  7. Management
    1. Eliminate the offending agent
    2. Consider Topical Corticosteroids
  8. References
    1. Jhun and DeClerck in Herbert (2015) EM:Rap 15(2): 9-11

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