Otolaryngology Book


Lemierre Syndrome

Aka: Lemierre Syndrome, Fusobacterium Pharyngitis
  1. See Also
    1. Pharyngitis
    2. Pharyngitis Causes
    3. Dysphagia
    4. Tonsillitis
    5. Group A Streptococcal Pharyngitis
    6. Peritonsillar Abscess
    7. Retropharyngeal Abscess
    8. Lemierre Syndrome
    9. Chronic Pharyngeal Carriage of Streptococcus pyogenes
    10. Tonsillectomy Indications
  2. Pathophysiology
    1. Infection by Fusobacterium necrophorium
      1. Responsible for 10% of acute Pharyngitis cases in young adults and adolescents
    2. Occurs with contiguous infection from Pharyngitis (typically) or Dental Infection to lateral pharyngeal space
    3. Results in septic Thrombophlebitis of internal Jugular Vein
  3. Epidemiology
    1. Adolescents and young adults make up majority of cases
  4. Signs
    1. Fever
    2. Tonsillar exudates
    3. Anterior Cervical Lymphadenopathy
    4. Cough absent
  5. Complications
    1. High morbidity and mortality
    2. Metastatic infection
    3. Septic pulmonary emboli
  6. Management: Consider empiric treatment
    1. Avoid Macrolides
    2. Penicillins
    3. Cephalosporins
  7. References
    1. Edson (2011) Internal Medicine, Mayo Conference, Kauai

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