Otolaryngology Book


Otitis Media Acute Treatment

Aka: Otitis Media Acute Treatment, Acute Otitis Media Management
  1. See Also
    1. Acute Otitis Media
    2. Otitis Media Diagnosis
    3. Observation Protocol for Acute Otitis Media Management
    4. Otitis Media Acute Treatment
    5. Otitis Media Prophylaxis
  2. Pitfalls
    1. Antihistamines and Decongestants are not useful
    2. Antibiotic dosages are often too low
  3. Risk factors: Treatment Failure
    1. Otitis Media within the last month
    2. Antibiotic within the last month
    3. Day Care attendance
    4. Bilateral Otitis Media
    5. Age less than 2 years old
    6. Age at first Otitis Media less than 6 months old
    7. Over 3 episodes Acute Otitis Media in last 6 months
  4. Protocol: Observation Protocol
    1. See Observation Protocol for Acute Otitis Media Management
    2. Strongly consider observation <48 hours of symptoms
      1. Age over 2 years OR
      2. Age 6-24 months if no severe symptoms
  5. Protocol: No Penicillin or Cephalosporin allergy
    1. Antibiotic duration
      1. Age under 2 years: 10 day course
      2. Age 2 to 5 years: 7 day course
      3. Age >5 years: 5 day course (if severe symptoms, use 7 day course)
    2. First Line
      1. Amoxicillin 80-90 mg/kg/day PO divided twice daily for 10 days
      2. If Penicillin Allergy
        1. Use Cephalosporins from second-line list below
          1. Move to third-line therapy if persistent symptoms and signs after 48-72 hours of antibiotics
        2. If unable to use Cephalosporins (due to allergy)
          1. Use alternative agents as shown below
      3. Indications for moving to second-line treatment
        1. Persistent symptoms with bulging, erythematous TM after 48-72 hours on first-line treatment
        2. Amoxicillin in last 30 days
        3. Concurrent Otitis Media with Conjunctivitis
    3. Second Line (10 day course)
      1. Amoxicillin with clavulanate (Augmentin) 90 mg/kg/day divided twice daily for 10 days
      2. Cefuroxime (Zinacef, Ceftin) 30 mg/kg/day divided twice daily for 10 days
      3. Cefprozil (Cefzil) 30 mg/kg/day divided twice daily for 10 days
      4. Cefdinir (Omnicef) 14 mg/kg/day divided one to two times daily fo 10 days
      5. Cefpodoxime (Vantin) 10 mg/kg divided twice daily for 10 days
    4. Third Line
      1. Strongly consider Tympanocentesis for Bacterial culture
      2. Ceftriaxone (Rocephin) 50 mg/kg IM daily for 3 days
      3. Clindamycin 30-40 mg/kg/day divided four times daily for 10 days
  6. Protocol: Agents if Penicillin and Cephalosporin Allergy
    1. Consider Tympanocentesis
    2. Clindamycin (Cleocin) 30-40 mg/kg/day (max 1800 mg) divided four times daily for 10 days
    3. Macrolide antibiotics (High Bacterial resistance rate)
      1. Erythromycin
      2. Clarithromycin (Biaxin) 15 mg/kg/day divided twice daily for 10 days
      3. Azithromycin (Zithromax)
        1. One dose of Azithromycin XR (Zmax) at 30 mg/kg (up to 1500 mg) or
        2. Three days of Azithromycin at 20 mg/kg/day once daily (up to 500 mg/day) or
          1. This high dose approached Augmentin efficacy in one study
          2. Arrieta (2003) Antimicrob Agents Chemother 47:3179 [PubMed]
        3. Azithromycin 10 mg/kg (max: 500 mg) day 1, then 5 mg/kg/day (max 250 mg) for 5 days
    4. Fluoroquinolones (avoid under age 16 years)
      1. Levofloxacin (Levaquin)
      2. Moxifloxacin (Avelox)
  7. Protocol: Topical agents if patent Tympanostomy Tubes
    1. Ciprofloxacin with Hydrocortisone (Cipro HC Otic) 3 drops twice daily for 7-10 days
    2. Ofloxacin (Floxin Otic) 5 drops (10 drops if over age 12) twice daily for 7-10 days
  8. Follow-up: Persistent Middle Ear Effusion (Otitis Media with Effusion)
    1. Natural course
      1. At 2 weeks: 70% have persistent effusion
      2. At 4 weeks: 40%
      3. At 2 months: 20%
      4. At 3 months: 10%
    2. Persistent effusion at 3 months
      1. See Otitis Media with Effusion
      2. Consider otolaryngology Consultation (including consideration for Tympanostomy Tube)
      3. If Tympanostomy Tubes not placed, recheck effusion every 3 months
  9. Precautions: Higher risk populations
    1. Infants under 8 weeks of age
      1. Associated with increased complications from Otitis Media
      2. All febrile infants under 4 weeks undergo Neonatal Sepsis evaluation (regardless of Otitis Media presense)
    2. Adults with recurrent otitits media (>2 episodes/year) or persistent Otitis Media (>6 weeks)
      1. Consider mechanical obstruction
      2. Consider naspharyngeal mass (especially blocking the eustachian tube)
  10. References
    1. (2016) Presc Lett 23(12): 68
    2. Aronovitz (2000) Clin Ther 22:29-39 [PubMed]
    3. Culpepper (1997) JAMA 278:1643-5 [PubMed]
    4. Del Mar (1997) BMJ 314:1526-9 [PubMed]
    5. Dowell (1998) Am Fam Physician 58:1113-23 [PubMed]
    6. Harmes (2013) Am Fam Physician 88(7):435-40 [PubMed]
    7. Hoppe (1998) Am J Health Syst Pharm 55:1881-97 [PubMed]
    8. Lieberthal (2013) Pediatrics 131(3): e964-99 [PubMed]
    9. Pichichero (2000) Ann Otol Rhinol Laryngol 109:2-10 [PubMed]
    10. Pichichero (2000) Am Fam Physician 61(8):2410-6 [PubMed]

Acute suppurative otitis media (C0271431)

Concepts Disease or Syndrome (T047)
ICD9 382.0
ICD10 H66.0
SnomedCT 42337005, 155226009, 194283000, 194281003
English ASOM, Acute supp. otitis media NOS, Acute suppurative otitis media NOS, acute suppurative otitis media (diagnosis), acute suppurative otitis media, Otitis media suppurative acute, Otitis media suppurative acute NOS, Otitis media;suppurative;acute, acute purulent otitis media, Acute suppurative otitis media NOS (disorder), Acute purulent otitis media, ASOM - Acute suppurative otitis media, Acute suppurative otitis media (disorder), otitis; media, acute, purulent, otitis; media, acute, suppurative, otitis; media, purulent, acute, otitis; media, suppurative, acute, suppurative; otitis media, acute, Acute suppurative otitis media, NOS, Acute suppurative otitis media (disorder) [Ambiguous], Acute otitis media, purulent, Acute suppurative otitis media
Dutch otitis media etterend acuut, etterende otitis media acuut NAO, acute etterende otitis media, etterig; otitis media, acuut, otitis; media, acuut, etterig, otitis; media, acuut, purulent, otitis; media, etterig, acuut, otitis; media, purulent, acuut, Acute etterige otitis media
French Otite moyenne suppurée aiguë, Otite moyenne suppurée aiguë SAI
German akute eitrige Otitis media, Otitis media eitrig akut NNB, Otitis media eitrig akut, Akute eitrige Otitis media
Italian Otite media suppurativa acuta, Otite media acuta suppurativa, Otite media suppurativa acuta NAS
Portuguese Otite média purulenta aguda, Otite média supurativa aguda NE
Spanish Otitis media purulenta aguda NEOM, Otitis media supurativa aguda, Otitis media aguda supurativa, otitis media aguda supurativa, SAI, otitis media aguda supurativa, SAI (trastorno), otitis media aguda purulenta, otitis media aguda supurativa (concepto no activo), otitis media aguda supurativa (trastorno), otitis media aguda supurativa
Japanese 急性化膿性中耳炎, 急性化膿性中耳炎NOS, キュウセイカノウセイチュウジエンNOS, キュウセイカノウショウチュウジエン, キュウセイカノウセイチュウジエン
Czech Akutní hnisavá otitis media, Akutní hnisavá otitis media NOS
Korean 급성 화농성 중이염
Hungarian heveny gennyes középfülgyulladás, Otitis media suppurativa acuta, Otitis media suppurativa acuta k.m.n.
Derived from the NIH UMLS (Unified Medical Language System)

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