Otolaryngology Book

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Allergic Triad

Aka: Allergic Triad, Aspirin Induced Asthma, Aspirin Allergy
  1. Definition
    1. Allergic constellation centered around Aspirin Allergy
  2. Associated Conditions
    1. Aspirin-induced Asthma
    2. Rhinorrhea
    3. Nasal Polyps
    4. Chronic Sinusitis
    5. Conjunctival edema
  3. Course
    1. Onset as perennial Vasomotor Rhinitis
    2. Develops into hyperplastic Rhinosinusitis, Nasal Polyps
  4. Causes
    1. Aspirin
    2. Cross-reactivity with NSAIDs
      1. Indomethacin
      2. Naproxen
      3. Ibuprofen
      4. Fenoprofen
      5. Mefenamic acid
      6. Phenylbutazone
  5. Management
    1. Avoid Aspirin and causative NSAIDs above
    2. Use safe alternative Analgesics instead
      1. Salsalate
      2. Acetaminophen
    3. Treat Aspirin-induced Asthma
      1. Leukotriene modifiers (e.g. Sinulair)

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