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Oral Mucosa Hyperpigmentation
Aka: Oral Mucosa Hyperpigmentation, Melanin Pigmentation of Oral Mucosa, Oral Hyperpigmentation, Oral Melanoplakia
- See Also
- Oral Mucosa
- Hyperpigmentation
- Medication Causes of Hyperpigmentation
- Tooth Discoloration
- Causes
- See Medication Causes of Hyperpigmentation
- Adrenal Insufficiency
- May be associated with Candidiasis in autoimmune polyendocrinopathy-Candidiasis-ectodermal dystrophy syndrome
- Darker pigmentation related to ethnicity
- Tobacco Abuse
- Medication Causes of Hyperpigmentation
- Neurofibromatosis 1
- McCune-Albright Syndrome
- Peutz-Jeghers Syndrome
- Differential Diagnosis
- See Tooth Discoloration
- Oral Melanoma
- Rare, but devastating outcomes if missed when early, focal
- Management
- Exclude Melanoma
- Eliminate or reduce dosing of causative agents
- Consider Tooth Discoloration causes that may be discoloring mucosa as well
- Refractory cases
- Surgical mucosal stripping of hyperpigmented tissue (e.g. laser, Cryotherapy, scalpel)
- References
- Glick (2020) Am Fam Physician 102(10):613-21 [PubMed]