Dermatology Book

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Topical Antiseptic

Aka: Topical Antiseptic, Topical Disinfectants, Local Anti-Infective Agents, Skin Preparation, Chlorhexidine, Hibiclens, Povidone Iodine, Povidone-Iodine, Betadine
  1. Indications
    1. Antseptics are applied prior to procedures in which the skin is broken
  2. Preparations
    1. Chlorhexidine (Hibiclens)
      1. Often preferred as Topical Anesthetic prior to procedures
      2. Avoid Chlorhexidine near eyes (irritation) and inside ear canal (ototoxic)
    2. Povidone Iodine (Betadine)
      1. Not affective until it dries
    3. Isopropyl Alcohol 70%
    4. Hydrogen Peroxide
  3. Resources
    1. Antiseptics (DermNetNZ)
      1. https://dermnetnz.org/topics/antiseptic
    2. Antiseptics (Stat Pearls)
      1. https://www.ncbi.nlm.nih.gov/books/NBK507853/
  4. References
    1. McDonnell (1999) Clin Microbiol Rev 12(1):147-79 +PMID:9880479 [PubMed]
      1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88911/
Medication Costs
Chlorhexidine Gluconate (on 6/18/2017 at Walmart.com)
Chlorhexidine Gluconate 0.12% soln (473ml bottle) #1 bottle for $4.00 $4.00 each
Chlorhexidine Gluconate 0.12% soln (473ml bottle) #3 bottle for $10.00 $3.33 each
chlorhexidine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
CHLORHEXIDINE 0.12% RINSE Generic $0.01 per ml
povidone-iodine (on 1/18/2017 at Medicaid.Gov Pharmacy Drug pricing)
POVIDONE-IODINE 10% OINTMENT Generic OTC $0.05 per gram
POVIDONE-IODINE 10% SOLUTION Generic OTC $0.01 per ml
betadine (on 4/19/2017 at Medicaid.Gov Pharmacy Drug pricing)
BETADINE 10% SOLUTION Generic OTC $0.01 per ml
BETADINE 7.5% SKIN CLEANSER OTC $0.07 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Anti-Infective Agents, Local (C0003205)

Definition (NCI) A natural or synthetic agent used for local application on skin, mucosa, or cavities, a Topical Anti-Infective Agent, formulated as a sterile solution or cream, commonly displays therapeutic or prophylactic antibiotic properties against infectious viral, bacterial, or protozoal agents by inhibiting growth and survival. (NCI04)
Definition (MSH) Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Definition (CSP) substances used topically on humans and other animals that destroy harmful microorganisms or inhibit their growth or activity.
Concepts Pharmacologic Substance (T121)
MSH D000891
SnomedCT 14319004, 373308008
English Agents, Local Anti-Infective, Agents, Local Antiinfective, Anti Infective Agents, Local, Antiinfective Agents, Local, Antiseptics, Local Anti Infective Agents, Local Anti-Infective Agents, Local Antiinfective Agents, local antiinfective agent, Agents, Topical Anti-Infective, Agents, Topical Antiinfective, Anti Infective Agents, Topical, Anti-Infective Agents, Topical, Antiinfective Agents, Topical, Topical Anti Infective Agents, Topical Anti-Infective Agents, Topical Antiinfective Agents, LOCAL ANTIINFECT AGENTS, ANTI INFECT AGENTS LOCAL, LOCAL ANTI INFECT AGENTS, ANTIINFECT AGENTS TOPICAL, TOPICAL ANTIINFECT AGENTS, ANTIINFECTIVE AGENTS LOCAL, ANTI INFECT AGENTS TOPICAL, ANTIINFECTIVE AGENTS TOPICAL, ANTIINFECT AGENTS LOCAL, TOPICAL ANTI INFECT AGENTS, antiseptic agents, local anti-infective agents, antiseptic agents (medication), Antiseptic, Antiseptic Agent [TC], Antiseptic Agent, topical anti-infective, local antiseptic, antiseptics, antiseptic, Local anti-infective (product), Local anti-infective, Local antiseptic, Local anti-infective (substance), Anti-Infective Agents, Local, Local anti-infective, NOS, Local antiseptic, NOS, Topical Anti-Infective Agent
French Antiseptiques, Anti-infectieux locaux, Antiinfectieux locaux, Médicaments antiseptiques, Anti-infectieux local, Agents antiseptiques
Swedish Antiinfektiva medel, lokala
Czech antiinfekční látky lokální, antiseptika
Finnish Paikallismikrobilääkkeet
Italian Antinfettivi per uso topico, Antinfettivi per uso locale, Antisettici
Russian PROTIVOINFEKTSIONNYE SREDSTVA LOKAL'NYE, ANTISEPTICHESKIE SREDSTVA, ANTISEPTIKI, PROTIVOINFEKTSIONNYE SREDSTVA MESTNYE, АНТИСЕПТИКИ, АНТИСЕПТИЧЕСКИЕ СРЕДСТВА, ПРОТИВОИНФЕКЦИОННЫЕ СРЕДСТВА ЛОКАЛЬНЫЕ, ПРОТИВОИНФЕКЦИОННЫЕ СРЕДСТВА МЕСТНЫЕ
Croatian ANTIMIKROBNA SREDSTVA, LOKALNA
Polish Leki odkażające miejscowo
Japanese 局所抗感染薬, 局所性抗感染剤, 局所的抗感染薬, 抗感染剤-局所性, 防腐薬(組織), 抗感染薬-局所性
Portuguese Antissépticos, Anti-Infecciosos Tópicos, Anti-Infecciosos Locais, Agentes Anti-Infecciosos Locais, Fármacos Anti-Infecciosos Locais, Agentes Anti-Infecciosos Tópicos, Agentes Antissépticos
Spanish Antiinfecciosos Locales, antiséptico local (producto), antiséptico local, antinfeccioso local, antinfeccioso local (sustancia), Agentes Antiinfecciosos Locales, Fármacos Antiinfecciosos Locales, antiséptico local (sustancia), Agentes Antiinfecciosos Tópicos, Antisépticos
German Antiseptika, Antiinfektiöse Mittel, lokal anwendbare, Antiinfektiöse Mittel, örtlich anwendbare
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Chlorhexidine (C0008196)

Definition (NCI) A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Definition (MSH) A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Definition (CSP) disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Definition (PDQ) A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41544&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41544&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C364" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002710
SnomedCT 17112005, 373568007, 96316004
LNC LP128648-5
English Chlorhexidine, 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, CHLORHEXIDINE, Chlorhexidine [Chemical/Ingredient], chlorhexidine, Chlorhexidine (product), Chlorhexidine (substance), Chlorhexidine -RETIRED-
Swedish Klorhexidin
Czech chlorhexidin
Finnish Klooriheksidiini
Russian KHLORGEKSIDIN, ХЛОРГЕКСИДИН
Croatian CHLORHEXIDINE
Polish Chlorheksydyna
Japanese クロルヘキシジン, 塩酸クロルヘキシジン
Norwegian Klorheksidin
Spanish clorhexidina-RETIRADO- (concepto no activo), clorhexidina-RETIRADO-, clorhexidina (producto), clorhexidina (sustancia), clorhexidina, Clorhexidina
French Chlorhexidine
German Chlorhexidin
Italian Cloressidina
Portuguese Clorexidina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Disinfectants (C0012682)

Definition (NCI_NCI-GLOSS) Any substance or process that is used primarily on non-living objects to kill germs, such as viruses, bacteria, and other microorganisms that can cause infection and disease. Most disinfectants are harsh chemicals but sometimes heat or radiation may be used.
Definition (SPN) A liquid chemical sterilant/high level disinfectant is a germicide that is intended for use as the terminal step in processing critical and semicritical medical devices prior to patient use. Critical devices make contact with normally sterile tissue or body spaces during use. Semicritical devices make contact during use with mucous membranes or nonintact skin.
Definition (CSP) substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity; they are distinguished from antiseptics, which are local antiinfective agents used on humans and other animals.
Definition (MSH) Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Concepts Substance (T167)
MSH D004202
SnomedCT 89216004, 311942001
English DISINFECTANT, MEDICAL DEVICES, STERILANT, MEDICAL DEVICES, Sterilants, disinfectants (medication), disinfectants, disinfectant, sterilant, Disinfectants, Disinfectant, Disinfectant (substance), Disinfectant, NOS, Disinfectant (substance) [Ambiguous]
French Agents désinfectants, Produits désinfectants, Désinfectants
Swedish Desinfektionsmedel
Czech dezinficiencia, dezinfekční prostředky
Finnish Desinfektioaineet
Russian DEZINFEKTSIONNYE SREDSTVA, DEZINFITSIRUIUSHCHIE SREDSTVA, ДЕЗИНФЕКЦИОННЫЕ СРЕДСТВА, ДЕЗИНФИЦИРУЮЩИЕ СРЕДСТВА
Croatian DEZINFICIJENSI
Polish Środki dezynfekujące
Japanese 殺菌剤, 消毒剤, 殺菌薬, 消毒薬, 殺菌消毒剤
Norwegian Not Translated[Disinfectants]
Spanish desinfectante (concepto no activo), desinfectante (sustancia), desinfectante, Desinfectantes
German Desinfektionsmittel
Italian Disinfettanti
Portuguese Desinfetantes
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Povidone-Iodine (C0032857)

Definition (NCI) An iodophor solution containing a water-soluble complex of iodine and polyvinylpyrrolidone (PVP) with broad microbicidal activity. Free iodine, slowly liberated from the polyvinylpyrrolidone iodine (PVPI) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow release of iodine from the PVPI complex in solution minimizes iodine toxicity towards mammalian cells.
Definition (MSH) An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D011206
SnomedCT 386989006, 111144003, 331314000, 326293001
English Polyvinylpyrrolidone Iodine, Povidone-Iodine, PVP-I, PVP-Iodine, PVP Iodine, Povidone Iodine, 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine, Povidone-iodine [gyn], Povidone-iodine [mouth], Povidone-Iodines, PVP-Iodines, Polyvinylpyrrolidone Iodines, Povidone-iodine [gynaecological use], Povidone-iodine [gynecological use], povidone-iodine (medication), povidone-iodine, Povidone-Iodine [Chemical/Ingredient], POVIDONE-IODINE, iodine pvp, iodine povidone, pvp-iodine, pvp iodine, pvp-i, povidone iodine, Povidone-iodine [mouth] (product), Povidone-iodine [gynecological use] (product), PVP iodine, Povidone iodine, Povidone-iodine, Povidone-iodine product, Povidone iodine (product), Povidone iodine (substance), Povidone-iodine [gynecological use] (substance), Povidone-iodine [mouth] (substance), POVIDONE IODINE
French Polyvinylpyrrolidone iodée, Polyvidone iodée, Povidone iodée, Polyvidone-iode, Polyvinylpyrrolidone-iode, Povidone-iode
Swedish Povidonjod
Czech povidon-jod, betadine, polyvinylpyrrolidon-jod, jodovaný povidon
Finnish Povidonijodi
Russian POLIVINILPIRROLIDON-IOD, POVIDON-IOD, POLIVINILPIRROLIDONA IODID, ПОВИДОН-ИОД, ПОЛИВИНИЛПИРРОЛИДОНА ИОДИД, ПОЛИВИНИЛПИРРОЛИДОН-ИОД
Spanish polividona yodada (sustancia), polividona yodada, PVP Yodado, Povidona Yodada, yodopovidona [uso ginecológico], iodopovidona (bucal), yodopovidona [uso ginecológico] (producto), iodopovidona (bucal) (producto), Yodopovidona, yodopovidona (producto), yodopovidona (sustancia), yodopovidona, Polivinilpirrolidona Yodada
Japanese ポビドンよう素, ポリビニルピロリドンよう素, ポビドン・ヨード, ポリビニルピロリドンヨード, ポビドンヨード, PVPヨード
Polish Jodopowidon
Norwegian Povidon-jod
Portuguese Iodo Povidine, PVP-I, Polivinilpirrolidona-Iodo, Povidona-Iodo, PVP-Iodo
German PVP-Iod, Polyvinylpyrrolidon-Iod, Povidon-Iod-Komplex
Italian Povidone iodio
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Antiseptic preparation (C0443072)

Concepts Pharmacologic Substance (T121)
SnomedCT 261276004
English Antiseptic preparation, Antiseptic preparation (product), Antiseptic preparation (substance)
Spanish preparado antiséptico (producto), preparado antiséptico
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Betadine (C0699524)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011206
English Betadines, Betadine antiseptic, betadine, Betadine
French Bétadine
Norwegian Betadine
Czech Betadine
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Hibiclens (C0728728)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C010882
English Hibiclens, hibiclens
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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