Dermatology Book

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Imiquimod

Aka: Imiquimod, Aldara
  1. Indication
    1. Genital Wart
    2. Recalcitrant Common Warts (not FDA approved)
    3. Molluscum Contagiosum (not FDA approved)
  2. Contraindications
    1. Do not use on mucous membranes
  3. Precautions
    1. Weakens Condoms and diaphragms
    2. Avoid sexual contact when cream is on skin
  4. Dosing
    1. General
      1. Apply thin layer to external visible lesions
      2. Rub in cream until it disappears
      3. Wash off with soap and water in 6-10 hours
    2. Genital Warts
      1. Apply 5% cream to affected area qhs for 3 nights/week
      2. Apply at bedtime and wash off in 6-10 hours
      3. May repeat weekly cycles for up to 16 weeks
    3. Recalcitrant warts
      1. Apply 3 times per week for a maximum of 16 weeks
      2. Apparently very effective if extensive involvement
    4. Molloscum contagiosum
      1. Apply to skin lesion for 6-10 hours, then wash off
      2. Apply 3 times weekly for 4 to 16 weeks
  5. References
    1. Edwards (2000) J Am Acad Dermatol 43:S12-7 [PubMed]
Medication Costs
imiquimod (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
IMIQUIMOD 5% CREAM PACKET Generic $2.41 each
aldara (on 8/17/2016 at Medicaid.Gov Pharmacy Drug pricing)
ALDARA 5% CREAM Generic $10.84 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

imiquimod (C0165032)

Definition (NCI_NCI-GLOSS) A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Imiquimod is a type of biological response modifier.
Definition (NCI) A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04)
Definition (PDQ) A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38558&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=38558&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1431" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C056493
SnomedCT 108939005, 386941002
English 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine, 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-, imiquimod, 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline, IMQ, imiquimod (medication), wart therapeutic agents imiquimod, imiquimod [Chemical/Ingredient], IMIQUIMOD, Imiquimod, Imiquimod (product), Imiquimod (substance)
Spanish imiquimod (producto), imiquimod (sustancia), imiquimod
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Aldara (C0718327)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C056493
English aldara, 3M Brand of Imiquimod, Aldara
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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