//fpnotebook.com/
Comedolytic
Aka: Comedolytic
- See Also
- Keratolytic
- Acne Vulgaris Pharmacologic Management
- Indication
- Acne Vulgaris
- Approach
- Comedolytics result in similar effect after 90 days
- Start with less irritating agents (see below)
- Apply skin products in layers
- First, apply Comedolytic
- Next, apply Skin Lubricant (skin Moisturizer)
- Last, apply sun screen
- (2017) Presc Lett 24(1): 3
- Preparations: Standard Comedolytics
- Benzoyl Peroxide (Ambi 10, Dermoxyl, Vanoxide and other OTC)
- Salicylic acid (Buf-Puf and other OTC)
- Tretinoin (Retin-A)
- Adapalene (Differin, 0.1% gel is OTC as of 2017)
- Trifarotene (Aklief)
- Expensive new Retinoid (45 g for $560) released in 2020 that is pump dispensed cream
- Marketed as a more specific Retinoid with the presumption that it is better tolerated (but without convincing evidence)
- Other generic Retinoids (e.g. Differin) is preferred
- References
- (2020) Presc Lett 27(2): 8
- Preparations: Less Irritating Comedolytics
- Creams are less irritating than gels
- Benzoyl Peroxide 2.5% water-based
- Tretinoin agents
- Retin A Micro (Tretinoin gel microsphere)
- Avita
- Adapalene (Differin)
- Better tolerated than Tretinoin
- Preparations: Combination agents (Comedolytic with antibiotic)
- Refrigeration required
- Erythromycin with Benzoyl Peroxide (Benzamycin)
- Refrigeration not required
- Benzoyl Peroxide, Glycolic Acid, Zinc (TRIAZ)
- Clindamycin with Benzoyl Peroxide Gel
- Preparations: Special indications
- Most irritating and potent agents
- Tazorac 0.1% gel qod
- Pregnancy
- Azelaic Acid (Azelex)
- References
- Kaplan (2001) CMEA Medicine Lecture, San Diego