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Dermatologic Medications in Pregnancy
Aka: Dermatologic Medications in Pregnancy, Topical Medications in Pregnancy, Dermatologic Medications in Lactation, Topical Medications in Lactation
- Background
- Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
- http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
- Although FDA Pregnancy Categories are no longer FDA designated, they are included here
- As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
- Preparations: Pregnancy
- Topical Corticosteroids
- Low potency Topical Corticosteroids may be used in pregnancy
- Avoid high potency Topical Corticosteroids in pregnancy due to risk of low birth weight
- Topical NSAIDs (e.g. topical diclofenac or Pennsaid)
- Avoid in pregnancy
- Topical benzocaine
- Safe for limited use in pregnancy
- Topical Retinoids (e.g. Tretinoin, Adapalene)
- Avoid Retinoids in pregnancy (Teratogenic)
- Topical Calcineurin Inhibitors (Protopic, Elidel)
- Avoid in pregnancy (theoretical risk of prematurity and low birth weight)
- Preparations: Lactation
- Topical Corticosteroids
- Avoid use on the nipple in Lactation (due to ingestion risk by infant)
- Topical NSAIDs (e.g. topical diclofenac or Pennsaid)
- Appear to be safe in Lactation
- Topical benzocaine
- Avoid use on the nipple in Lactation (due to ingestion risk by infant with associated Methemoglobinemia)
- Topical Retinoids (e.g. Tretinoin, Adapalene)
- Tretinoin and Adapalene appear safe in Lactation, but limit the use of Tazarotene
- Topical Calcineurin Inhibitors (Protopic, Elidel)
- Appear to be safe in Lactation
- References
- (2014) Presc Lett 21(10): 58
- Tyler (2013) J Am Acad Dermatol 68(4): 663-71 [PubMed]