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Linear IgA Dermatosis
Aka: Linear IgA Dermatosis, Linear IgA Bullous Dermatosis
- See Also
- Bullous Disease
- Chronic Bullous Disease of Childhood
- Epidemiology
- Onset over age 30 years
- Pathophysiology
- Autoimmune bullous disorder
- Variant of Chronic Bullous Disease of Childhood
- Symptoms
- Pruritus
- Signs
- Annular Lesions
- Papules (may be excoriated and crusted)
- Vesicles
- Bullae
- Distribution
- Symmetric involvement on extensor surfaces
- Elbows, knees, and buttocks affected
- Mucusa involvement may occur (Conjunctiva, oral)
- Labs
- Histology
- Subepidermal Blisters
- Inflammatory infiltrates at basement membrane zone
- Immunofluorescence
- IgA deposition along basement membrane
- Management
- First Line: Dapsone or Sulfapyridine
- See Dapsone (requires G6PD and monitoring of CBC)
- Adjunct: Low dose Prednisone initially
- Course
- Variable course that may last for years
- References
- Bickle (2002) Am Fam Physician 65(9):1861-70 [PubMed]
- Cotell (2000) Am J Emerg Med 18(3):288-99 [PubMed]