Cardiovascular Medicine Book



Medication Causes of Orthostatic Hypotension

Aka: Medication Causes of Orthostatic Hypotension, Orthostatic Hypotension due to Medication, Drug-Induced Orthostatic Hypotension, Drug-Induced Hypotension, Drug-Induced Syncope, Medication-Induced Syncope
  1. Causes: Cardiac Medications
    1. Methyldopa
    2. Clonidine
    3. Antiarrhythmic medications (esp. Type Ia such as Quinidine)
      1. Digitalis (Atrioventricular Block, Ventricular Tachycardia)
    4. Alpha adrenergic blockers (e.g. Prazosin, Doxazosin, Terazosin)
    5. Beta Blockers (e.g. Atenolol, Metoprolol)
    6. Alpha-Beta Blockers (Carvedilol, Labetalol)
    7. Diuretics (e.g. Furosemide) due to multiple mechanisms (Hypovolemia, Hypokalemia, Hypomagnesemia)
    8. Vasodilator medications
      1. Nitrates (Nitroglycerin)
      2. Calcium Channel Blockers
      3. ACE Inhibitors (e.g. Lisinopril)
      4. Hydralazine
      5. Dipyridamole (Persantine)
      6. Reserpine
  2. Causes: Genitourinary Medications
    1. Phosphodiesterase type 5 inhibitors (e.g. Sildenafil or Viagra)
    2. Anticholinergics (e.g. Oxybutynin or Ditropan)
    3. Flibanserin (Addyi)
  3. Causes: Neuropsychiatric Agents
    1. Parkinsonism agents (Levodopa-Carbidopa, Bromocriptine)
    2. Barbiturates
    3. MAO inhibitors (e.g. Phenelzine)
    4. Tricyclic Antidepressants (e.g. Amitriptyline, Doxepin, Trazodone)
    5. Antipsychotics (e.g. Chlorpromazine, Clozapine, thioridazine)
    6. Muscle relaxants (e.g. Baclofen, Cyclobenzaprine, Methocarbamol, Tizanidine)
    7. Tricyclic Antidepressants
  4. Causes: Miscellaneous
    1. See Anticholinergic Medication
    2. Opioids (e.g. Morphine)
    3. Antidiabetes medications (e.g. Insulin)
    4. Phenothiazines
    5. Chemotherapy
      1. Vincristine
      2. Adriamycin (Doxorubicin)
  5. References
    1. Gupta (2007) Am J Med 120(10): 841-7 [PubMed]
    2. Kim (2022) Am Fam Physician 105(1): 39-49 [PubMed]

Drug-induced hypotension (C0340858)

Concepts Pathologic Function (T046)
ICD10 I95.2
SnomedCT 195507005, 234171009
German Hypotonie durch Arzneimittel
Korean 약물에 의한 저혈압
English Drug-induced hypotension (diagnosis), hypotension drug-induced, Hypotension due to drugs, Drug-induced hypotension, Drug-induced hypotension (disorder), drug; hypotension, hypotension; due to drugs
Dutch geneesmiddel; hypotensie, hypotensie; door geneesmiddelen, Hypotensie door geneesmiddelen
Spanish hipotensión inducida por fármacos (trastorno), hipotensión inducida por fármacos
Derived from the NIH UMLS (Unified Medical Language System)

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