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Labetalol
Aka: Labetalol, Trandate
- See Also
- Alpha Adrenergic Antagonist
- Beta Blocker
- Indications
- Refractory Hypertension
- Very effective outpatient agent in oral form patients with Refractory Hypertension
- Hypertensive Emergency
- Nicardipine has replaced intravenous Labetalol for Hypertensive Emergency
- Difficult to achieve Blood Pressure control in Hypertensive Crisis despite titration
- Short acting
- Labetalol is a preferred agent when compared with Hydaralazine and Clonidine
- Mechanism
- Combination of classes
- Alpha Adrenergic Antagonist and
- Nonselective Beta Blocker
- Primary activity is as a negative inotrope
- Chronotropic effect is mild
- Dosing
- Oral: 100 mg PO bid (Maximum: 2400 mg/day)
- Intravenous: 20 mg IV q10 minutes (Maximum: 200 mg)