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Esmolol

Aka: Esmolol, Esmolol Hydrochloride, Brevibloc
  1. See Also
    1. Beta Blocker
  2. Mechanism
    1. Selective Beta Blocker
  3. Indications
    1. Atrial Fibrillation Rate Control
    2. Emergent Hypertension Management
  4. Pharmacokinetics
    1. Half-life: 9 minutes
      1. Rapidly metabolized by erythrocyte esterase
    2. Duration of action: 15-20 minutes
  5. Dosing: Intravenous
    1. Preparation: 2.5g (10 ml ampule) in 250 ml (10 mg/ml)
    2. Load: 250-500 ug/kg over 1 min (70 kg: 35 mg, 3.5 ml)
    3. Infusion:
      1. Start 25-50 ug/kg/min IV (70 kg: 10 ml/h)
      2. Titrate up 25-50 ug/kg q5 min to max 300 ug/kg/min

Brevibloc (C0591189)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C036604
English Brevibloc, Baxter brand of esmolol hydrochloride, Boots brand of esmolol hydrochloride, Prasfarma brand of esmolol hydrochloride, Rhône-Poulenc Rorer brand of esmolol hydrochloride
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Esmolol hydrochloride (C0700606)

Definition (NCI) The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C036604
SnomedCT 35318005, 318624002
English 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoic Acid Methyl Ester HCl, (+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Hydrochloride, Esmolol Hydrochloride, esmolol hydrochloride (medication), ESMOLOL HYDROCHLORIDE, esmolol HCl, Esmolol hydrochloride, Esmolol hydrochloride product, Esmolol hydrochloride (substance), Esmolol hydrochloride product (product), Esmolol hydrochloride product (substance), esmolol hydrochloride
Spanish producto con clorhidrato de esmolol (producto), clorhidrato de esmolol (producto), producto con clorhidrato de esmolol, clorhidrato de esmolol (sustancia), clorhidrato de esmolol, producto (producto), clorhidrato de esmolol, producto, clorhidrato de esmolol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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